1921
Volume 73, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

To assess clinical findings associated with infection, 192 school children in a filariasis-endemic area of Haiti underwent physical and ultrasonographic examinations and testing for circulating filarial antigen (CFA). The CFA-positive children were more likely than CFA-negative children to have severe interdigital lesions (≥1 macerated lesion with involvement of ≥4 toe web spaces) ( < 0.0001) and inguinal ( = 0.003) or crural ( = 0.004) lymph node pathology. In multivariate analysis, CFA positivity remained a significant predictor for severe interdigital lesions ( = 0.006) and inguinal lymph node pathology ( = 0.05). Ultrasound detected adult worms and lymphangectasia (diameter = 2.0–4.0 mm) in 11 (10.8%) CFA-positive children. Among CFA-positive children, ultrasonographic detection of adult worms was associated with inguinal ( = 0.01) and crural ( = 0.004) lymph node pathology and advanced pubertal stage (sexual maturity rating = 3–5) ( = 0.02). This is the first study to associate interdigital lesions with filarial infection in children.

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  • Received : 12 Apr 2005
  • Accepted : 16 May 2005

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