Volume 73, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Lactoferrin (LF) is an important biologic molecule with many functions, one of which is antimicrobial defense. We evaluated the growth-inhibiting effects of four types of LF (native LF, Fe-bound [holo] LF, Fe-free [apo] LF, and LF hydrolyzate) on the growth of and . The growth of was significantly suppressed in media containing apo LF, but was not inhibited in media containing native LF, holo LF, or LF hydrolyzate. The growth of was not inhibited by media containing native LF, holo LF, or apo LF. These data indicate that apo LF had the strongest inhibitory effect on . This may have been caused by inactivation or inhibition of a growth factor in the culture medium.


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  • Received : 15 Sep 2004
  • Accepted : 10 Jan 2005

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