1921
Volume 73, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Despite different recommendations from WHO and national authorities, artesunate monotherapy is increasingly used for treating African children with malaria. A 5-day course of oral artesunate (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day 28 cure rate of 90% (45 of 50 patients; CI 78–97%) in Gabonese children aged between 2 and 18 months. Artesunate was well tolerated, and no severe adverse events were reported.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2005.73.705
2005-10-01
2019-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/73/4/0730705.html?itemId=/content/journals/10.4269/ajtmh.2005.73.705&mimeType=html&fmt=ahah

References

  1. Bjorkman A, Phillips-Howard PA, 1990. The epidemiology of drug-resistant malaria. Trans R Soc Trop Med Hyg 84 : 177–180. [Google Scholar]
  2. Gatton ML, Martin LB, Cheng Q, 2004. Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum. Antimicrob Agents Chemother 48 : 2116–2123. [Google Scholar]
  3. Roper C, Pearce R, Bredenkamp B, Gumede J, Drakeley C, Mosha F, Chandramohan D, Sharp B, 2003. Antifolate antimalarial resistance in southeast Africa: a population-based analysis. Lancet 361 : 1174–1181. [Google Scholar]
  4. Winkler S, Brandts C, Wernsdorfer WH, Graninger W, Bienzle U, Kremsner PG, 1994. Drug sensitivity of Plasmodium falciparum in Gabon. Activity correlations between various antimalarials. Trop Med Parasitol 45 : 214–218. [Google Scholar]
  5. Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T, 2004. Intercontinental spread of pyrimethamine-resistant malaria. Science 305 : 1124. [Google Scholar]
  6. Pukrittayakamee S, Supanaranond W, Looareesuwan S, Vanijanonta S, White NJ, 1994. Quinine in severe falciparum malaria: evidence of declining efficacy in Thailand. Trans R Soc Trop Med Hyg 88 : 324–327. [Google Scholar]
  7. Kremsner PG, Krishna S, 2004. Antimalarial combinations. Lancet 364 : 285–294. [Google Scholar]
  8. Hien TT, White NJ, 1993. Qinghaosu. Lancet 341 : 603–608. [Google Scholar]
  9. Adjuik M, Babiker A, Garner P, Olliaro P, Taylor W, White N, 2004. Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363 : 9–17. [Google Scholar]
  10. Yeung S, Pongtavornpinyo W, Hastings IM, Mills AJ, White NJ, 2004. Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. Am J Trop Med Hyg 71 : 179–186. [Google Scholar]
  11. Borrmann S, Adegnika AA, Missinou MA, Binder RK, Issifou S, Schindler A, Matsiegui PB, Kun JF, Krishna S, Lell B, Kremsner PG, 2003. Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicrob Agents Chemother 47 : 901–904. [Google Scholar]
  12. Ittarat W, Pickard AL, Rattanasinganchan P, Wilairatana P, Looareesuwan S, Emery K, Low J, Udomsangpetch R, Meshnick SR, 2003. Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors. Am J Trop Med Hyg 68 : 147–152. [Google Scholar]
  13. Bunnag D, Viravan C, Looareesuwan S, Karbwang J, Harinasuta T, 1991. Double blind randomised clinical trial of two different regimens of oral artesunate in falciparum malaria. Southeast Asian J Trop Med Public Health 22 : 534–538. [Google Scholar]
  14. Bunnag D, Viravan C, Looareesuwan S, Karbwang J, Harinasuta T, 1991. Clinical trial of artesunate and artemether on multidrug resistant falciparum malaria in Thailand. A preliminary report. Southeast Asian J Trop Med Public Health 22 : 380–385. [Google Scholar]
  15. Bunnag D, Viravan C, Looareesuwan S, Karbwang J, Harinasuta T, 1991. Double blind randomised clinical trial of oral artesunate at once or twice daily dose in falciparum malaria. Southeast Asian J Trop Med Public Health 22 : 539–543. [Google Scholar]
  16. Alin MH, Kihamia CM, Bjorkman A, Bwijo BA, Premji Z, Mtey GJ, Ashton M, 1995. Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine. Am J Trop Med Hyg 53 : 639–645. [Google Scholar]
  17. Hassan AM, Ashton M, Kihamia CM, Mtey GJ, Bjorkman A, 1996. Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients. Trans R Soc Trop Med Hyg 90 : 61–65. [Google Scholar]
  18. Looareesuwan S, Wilairatana P, Vanijanonta S, Pitisuttithum P, Ratanapong Y, Andrial M, 1997. Monotherapy with sodium artesunate for uncomplicated falciparum malaria in Thailand: a comparison of 5- and 7-day regimens. Acta Trop 67 : 197–205. [Google Scholar]
  19. Price R, van Vugt M, Nosten F, Luxemburger C, Brockman A, Phaipun L, Chongsuphajaisiddhi T, White N, 1998. Artesunate versus artemether for the treatment of recrudescent multidrug-resistant falciparum malaria. Am J Trop Med Hyg 59 : 883–888. [Google Scholar]
  20. Gomez EA, Jurado MH, Cambon N, 2003. Randomised efficacy and safety study of two 3-day artesunate rectal capsule/mefloquine regimens versus artesunate alone for uncomplicated malaria in Ecuadorian children. Acta Trop 89 : 47–53. [Google Scholar]
  21. Sylla EH, Lell B, Kun JF, Kremsner PG, 2001. Plasmodium falciparum transmission intensity and infection rates in children in Gabon. Parasitol Res 87 : 530–533. [Google Scholar]
  22. Sylla EH, Kun JF, Kremsner PG, 2000. Mosquito distribution and entomological inoculation rates in three malaria-endemic areas in Gabon. Trans R Soc Trop Med Hyg 94 : 652–656. [Google Scholar]
  23. WHO, 2000. Severe and complicated malaria, 3rd edition. Trans R Soc Trop Med Hyg 94 (Suppl.1): S1–S90. [Google Scholar]
  24. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA, 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239 : 487–491. [Google Scholar]
  25. Djimde A, Plowe CV, Diop S, Dicko A, Wellems TE, Doumbo O, 1998. Use of antimalarial drugs in Mali: policy versus reality. Am J Trop Med Hyg 59 : 376–379. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.73.705
Loading
/content/journals/10.4269/ajtmh.2005.73.705
Loading

Data & Media loading...

  • Received : 22 Mar 2005
  • Accepted : 03 May 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error