1921
Volume 73, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Observations on infections in monkeys suggest that this host-parasite combination would be a suitable model for the testing of candidate vaccines against . To evaluate the normal course of infections, parasitemia in 52 splenectomized monkeys infected with were analyzed. The mean maximum parasite count for 31 monkeys after injection with trophozoite-infected erythrocytes was 77,580/μL. Twenty-one monkeys were infected via sporozoites, and prepatent periods ranged from 14 to 24 days with a median of 15 days. The mean maximum parasite count was 29,234/μL. The mean maximum parasite count for monkeys previously infected with Old World was 26,337/μL versus 56,362/μL for those previously infected with New World , possibly suggesting a closer antigenic relationship between and the Old World parasites.

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  • Received : 14 Jan 2005
  • Accepted : 07 Apr 2005

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