1921
Volume 73, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A cross-sectional study was undertaken to determine the prevalence of cryptosporidiosis and its clinical and laboratory pattern in Venezuelan HIV-infected patients ( = 397). At enrollment, they underwent thorough clinical history and physical examination and provided stool specimens for the identification of sp. and other parasites. sp. was identified in 59 subjects (15%). This infection was strongly associated with acute and chronic diarrhea, weight loss, CD4 counts below 100 cells/mm, older age in patients with leukopenia, and more than 5 stools per day when CD4 counts were below 100 cells/mm. In addition, patients with infection were less likely to be coinfected with (OR = 0.05, = 0.001). In fact, results of the current study confirm the worldwide importance of cryptosporidiosis as a clinically significant opportunistic infection associated with an advanced stage of immunosuppression.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2005.73.54
2005-07-01
2017-11-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/73/1/0730054.html?itemId=/content/journals/10.4269/ajtmh.2005.73.54&mimeType=html&fmt=ahah

References

  1. Guerrant R, 1997. Cryptosporidiosis: an emerging, highly infectious threat. Emerg Infect Dis 3 : 51–57.
  2. Griffith JK, 1998. Human cryptosporidiosis: epidemiology, transmission, clinical disease, treatment and diagnosis. Adv Parasitol 40 : 38–85.
  3. Pedersen C, Danner S, Lazzarin A, Glauser MP, Weber R, Katlama C, Barton SE, Lundgren JD, 1996. Epidemiology of cryptosporidiosis among European AIDS patients. Genitourin Med 72 : 128–131.
  4. Kartalija M, Sande M, 1999. Diarrhea and AIDS in the era of highly active anti-retroviral therapy. Clin Infect Dis 28 : 701–707.
  5. Chen X, Keithly J, Paya C, LaRusso N, 2002. Cryptosporidiosis. N Engl J Med 346 : 1723–1731.
  6. Núñez L, Arenas A, Comegna M, Guzmán M, 1999. Diarreas parasitarias en pacientes con infección por VIH. Revista Pan-americana de Infectología 3 : 10–16.
  7. Henricksen SA, Pohlenz JFL, 1981. Staining of Cryptosporidia by a modified Ziehl Neelsen technique. Acta Vet Scand 22 : 594–596.
  8. Wilson JD, Braunwald E, Isselbacher K, Petersdorf R, Martin J, Fauci A, Rout R, 1991. Harrison’s, Principles of Internal Medicine, 12th edition. Vol. 1. McGraw-Hill, International Edition. Appendix A-10.
  9. Leach Ch, Koo F, Kuhls T, Hilsenbeck S, Jenson H, 2000. Prevalence of Cryptosporidium parvum infection along the Texas-Mexico border and associated risk factors. Am J Trop Med Hyg 62 : 656–661.
  10. Navin T, Weber R, Vugia D, Rimlan D, Roberts J, Addis D, Visvesvara G, Wahlquist S, Hogan S, Gallager L, Juranek D, Schartz D, Wilcox CM, Stewart J, Thompson SE III, Bryan R, 1999. Declining CD4+ T-Lymphocyte counts are associated with increased risk of enteric parasitosis and chronic diarrhea: Results of a 3-year longitudinal study. J Acq Immune Defic Syndr 20 : 154–159.
  11. Certad G, Arenas-Pinto A, Pocaterra L, Ferrara G, Bello A, Castro J, Núñez L, 2003. Isosporiasis in venezuelan HIV infected adults: clinical characterization. Am J Trop Med Hyg 69 : 217–222.
  12. Arenas-Pinto A, Certad G, Ferrara G, Bello A, Castro J, Nuñez L, 2003. Association between parasitic intestinal infections and acute or chronic diarrhea in HIV infected patients in Caracas, Venezuela. Int J STD AIDS 14 : 487–492.
  13. Cimerman S, Cimerman B, Lewi S, 1999. Evaluation of the relationship between of intestinal parasitosis and risk factors for HIV infections in AIDS patients. Rev Soc Bras Med Trop 32 : 181–185.
  14. Cranendok RK, Kodde CJ, Chipete D, Zijlstra EE, Sluiters JF, 2003. Cryptosporidium parvum and Isospora belli infections among patients with and without diarrhea. East Afr Med J 80 : 393–394.
  15. Sauda FC, Zamarioli LA, Ebner Filhow W, Mello L deB, 1993. Prevalence of Cryptosporidium sp. and Isospora belli among AIDS patients attending Santos reference center for AIDS, Sao Paulo, Brazil. J Parasitology 79 : 454–456.
  16. Takahashi M, Omata Y, Oikawa H, Claveria F, Igarashi I, Sito A, Susuki N, 1993. Protective immune response of Isospora felis-infected mice against Babesia microti infection. J Vet Med Sci 55 : 587–590.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.73.54
Loading
/content/journals/10.4269/ajtmh.2005.73.54
Loading

Data & Media loading...

  • Received : 24 Apr 2004
  • Accepted : 19 Jan 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error