1921
Volume 73, Issue 5_suppl
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Prevalence of malaria-related anemia in disease-endemic regions of the American continents has been poorly studied. We describe the relationships between hemoglobin level and race, species, and days of illness in 150 Colombian patients with uncomplicated malaria diagnosed by thick blood smear. Hemoglobin was measured at admission and a standardized questionnaire was used to determine days of illness and other variables. Associations between hemoglobin and the variables were estimated and adjusted according to the other covariates using regression analysis. and were found in similar proportions and mild anemia was present in 50% of the patients. Volunteers were classified as Afro-Colombians (61%) and non-Afro-Colombians (39%). An inverse relationship between hemoglobin and days of illness was identified, and a statistical interaction was found between race and infection in determining the hemoglobin concentration. These observations could guide the design of research to better understand malarial anemia.

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2005-11-01
2017-11-24
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References

  1. Breman JG, 2001. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg 64 : 1–11.
  2. Hendrickse R, 1987. Malaria and child health. Ann Trop Med Parasitol 81 : 499–509.
  3. Brewster DR, Kwiatkowski D, White NJ, 1990. Neurological sequelae of cerebral malaria in children. Lancet 336 : 1039–1043.
  4. Nussenblatt V, Semba RD, 2002. Micronutrient malnutrition and the pathogenesis of malarial anemia. Acta Trop 82 : 321–337.
  5. Kalenga M, Nyembo M, Nshimba M, Foidart J, 2003. Anemia associated with malaria and intestinal helminthiasis in Lubumbashi. Sante Publique 15 : 413–421.
  6. Price RN, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen L, ter Kuile F, Chongsuphajaisiddhi T, White NJ, 2001. Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg 65 : 614–622.
  7. Waitumbi JN, Opollo MO, Muga RO, Misore AO, Stoute JA, 2000. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood 95 : 1481–1486.
  8. Breuer WV, Kutner S, Sylphen J, Ginsburg H, Cabantchik ZI, 1987. Covalent modification of the permeability pathways induced in the human erythrocyte membrane by the malarial parasite Plasmodium falciparum. J Cell Physiol 133 : 55–63.
  9. Facer CA, Bray RS, Brown J, 1979. Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. Incidence and class specificity. Clin Exp Immunol 35 : 119–127.
  10. Abdalla SH, Kasili FG, Weatherall DJ, 1983. The Coombs direct antiglobulin test in Kenyans. Trans R Soc Trop Med Hyg 77 : 99–102.
  11. Lyke K, Burges R, Cissoko Y, Sangare L, Dao M, Diarra I, Kone A, Harley R, Plowe C, Doumbo O, Sztein M, 2004. Serum levels of the proinflammatory cytokines interleukin-1β (IL-1β), IL-6, IL-8, IL-10, tumor necrosis factor α, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. Infect Immun 72 : 5630–5637.
  12. Grau GE, Taylor TE, Molyneux ME, Wirima JJ, Vassalli P, Hommel M, Lambert PH, 1989. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 320 : 1586–1591.
  13. McGuire W, Knight JC, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D, 1999. Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. J Infect Dis 179 : 287–290.
  14. Keller CC, Kremsner PG, Hittner JB, Misukonis MA, Weinberg JB, Perkins DJ, 2004. Elevated nitric oxide production in children with malaria anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. Infect Immun 72 : 4868–4873.
  15. Nussenblatt V, Mukasa G, Metzger A, Ndeezi G, Garrett E, Semba RD, 2001. Anemia and interleukin-10, tumor necrosis factor alpha, and erythropoietin levels among children with acute, uncomplicated Plasmodium falciparum malaria. Clin Diagn Lab Immunol 8 : 1164–1170.
  16. Chaisavaneeyakorn S, Othoro C, Shi Y, Otieno J, Chaiyaroj S, Lal A, Udhayakumar V, 2003. Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya. Clin Diagn Lab Immunol 10 : 362–366.
  17. Mendez F, Carrasquilla G, Muñoz A, 2000. Risk factors associated with malaria infection in an urban setting. Trans R Soc Trop Med Hyg 94 : 367–371.
  18. Gonzalez JM, Olano V, Vergara J, Arévalo-Herrera M, Carrasquilla G, Herrera S, Lopez JA, 1997. Unstable, low-level transmission of malaria on the Colombian Pacific Coast. Ann Trop Med Parasitol 91 : 349–358.
  19. Herrera S, Gómez A, Vera O, Vergara J, Valderrama-Aguirre A, Maestre A, Méndez F, Wang R, Chitnis CH, Yazdani SS, Arévalo-Herrera M, 2005. Antibody response to Plasmodium vivax antigens in Fy-negative individuals from the Colombian Pacific Coast. Am J Trop Med Hyg 73 (Suppl 5): 44–49.
  20. Pazzaglia G, Woodward WE, 1982. An analysis of the relationship of host factors to clinical falciparum malaria by multiple regression techniques. Am J Trop Med Hyg 31 : 202–210.
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  • Received : 10 May 2005
  • Accepted : 04 Aug 2005

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