1921
Volume 73, Issue 5_suppl
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The Duffy antigen (Fy) is necessary for invasion of human erythrocytes. Some populations have a highly prevalent Fy-negative phenotype; such persons are naturally protected from blood infection but are expected to completely support the pre-erythrocytic cycle, representing a valuable model for studying the immune response during these parasitic stages. We typed 214 individuals, mostly Afro-Colombians, from a -endemic area for Fy expression and determined the antibody response to pre-erythrocytic (sporozoites and CS) and blood-stage antigens (blood forms, merozoite surface protein 1, and Duffy binding protein [PvDBP]). Antibody titers to circumsporozoite protein, P11, and N-terminal peptides and the number of responders were similar in Fy-negative and Fy-positive individuals. The number of responders to sporozoites, blood forms, and PvDBP were different between these groups. Thus, Fy-negative individuals from malaria-endemic areas can be used to study the immune response to the liver phase without interference of the erythrocytic cycle.

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  • Received : 12 Apr 2005
  • Accepted : 17 Jun 2005

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