1921
Volume 73, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Despite control programs based on mass drug administration (MDA) of microfilaricidal compounds, Bancroftian lymphatic filariasis remains a problem in French Polynesia. For an alternative strategy to MDA, we investigated the potential role of to control filarial transmission. are intracellular α-proteobacteria endosymbionts that infect a broad range of insects and nematodes. These bacteria have a suspected role in the pathogenesis of filariasis. They also may be useful in mosquito control through cytoplasmic incompatibility. To detect and characterize these bacteria in the filarial and mosquito-vectors in French Polynesia, a survey was conducted on field-collected mosquitoes and microfilariae from infected people. Samples were analyzed by a polymerase chain reaction and gene sequencing. The results indicate that these bacteria are widespread. Sequence analysis of the and genes positioned the in cluster A and in cluster D. The implications for possible improved treatment and vector control are discussed.

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2005-08-01
2017-11-20
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References

  1. Bazzocchi C, Jamnongluk W, O’Neill SL, Anderson TJ, Genchi C, Bandi C, 2000. wsp gene sequences from the Wolbachia of filarial nematodes. Curr Microbiol 41 : 296–300.
  2. Bandi C, Anderson TJ, Genchi C, Blaxter ML, 1998. Phylogeny of Wolbachia in filarial nematodes. Proc R Soc Lond B Biol Sci 265 : 2407–2413.
  3. Taylor MJ, Hoerauf A, 1999. Wolbachia bacteria of filarial nematodes. Parasitol Today 15 : 437–442.
  4. Taylor, 2000. Elimination of lymphatic filariasis as a public health problem. Trans R Soc Trop Med Hyg 94 : 596–598.
  5. Bandi C, Trees AJ, Brattig NW, 2001. Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases. Vet Parasitol 98 : 215–238.
  6. Taylor MJ, 2003. Wolbachia in the inflammatory pathogenesis of human filariasis. Ann N Y Acad Sci 990 : 444–449.
  7. Hise AG, Gillette-Ferguson I, Pearlman E, 2004. The role of endosymbiotic Wolbachia bacteria in filarial disease. Cell Microbiol 6 : 97–104.
  8. Lamb TJ, Le Goff L, Kurniawan A, Guiliano DB, Fenn K, Blaxter ML, Read AF, Allen JE, 2004. Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. J Infect Dis 189 : 120–127.
  9. Bandi C, McCall JW, Genchi C, Corona S, Venco L, Sacchi L, 1999. Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts Wolbachia. Int J Parasitol 29 : 357–364.
  10. Smith HL, Rajan TV, 2000. Tetracycline inhibits development of the infective stage larvae of filarial nematodes in vitro. Exp Parasitol 95 : 265–270.
  11. Townson S, Hutton D, Siemienska J, Hollick L, Scanlon T, Tagboto SK, Taylor MJ, 2000. Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi. Ann Trop Med Parasitol 94 : 801–816.
  12. Langworthy NG, Renz A, Mackenstedt U, Henkle-Duhrsen K, de Bronsvoort MB, Tanya VN, Donnelly MJ, Trees AJ, 2000. Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia procedes worm death and suggests a dependent relationship. Proc R Soc Lond B Biol Sci 267 : 1063–1069.
  13. Taylor MJ, Hoerauf A, 2001. A new approach to the treatment of filariasis. Curr Opinion Infect Dis 14 : 727–731.
  14. Taylor MJ, Bilo K, Cross HF, Archer JP, Underwood AP, 1999. 16S rDNA phylogeny and ultrastructural characterization of Wolbachia intracellular bacteria of the filarial nematodes Brugia malayi, B. pahangi and Wuchereria bancrofti. Exp Parasitol 91 : 356–361.
  15. Hoti SL, Shridhar A, Das PK, 2003. Presence of Wolbachia endosymbionts in microfilariae of Wuchereria bancrofti (Spirurida: Onchocercidae) from different geographical regions in India. Mem Inst Oswaldo Cruz 98 : 1017–1019.
  16. Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW, 2003. Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol 192 : 211–216.
  17. Moulia-Pelat JP, Glaziou P, Chanteau S, Nguyen-Ngoc L, Marcet Y, Cardines R, Martin PM, Cartel JL, 1993. Periodicity of Wuchereria bancrofti var. pacifica filariasis in French Polynesia. Trop Med Parasitol 44 : 83–85.
  18. Pichon G, Treuil JP, 2004. Genetic determinism of parasitic circadian periodicity and subperiodicity in human filariasis. C R Biol 327 : 1087–1094.
  19. Sinkins SP, Braig HR, O’Neill SL, 1995. Wolbachia superinfections and the expression of cytoplasmic incompatibility. Proc R Soc Lond B Biol Sci 261 : 325–333.
  20. Stouthamer R, Breeuwer JA, Hurst GD, 1999. Wolbachia pipientis: microbial manipulator of arthropod reproduction. Annu Rev Microbiol 53 : 71–102.
  21. Dobson SL, Fox CW, Jiggins FM, 2002. The effect of Wolbachia-induced cytoplasmic incompatibility on host population size in natural and manipulated systems. Proc R Soc Lond B Biol Sci 269 : 437–445.
  22. Desowitz RS, Southgate BA, Mataika JU, 1973. Study on filariasis in the Pacific. 3. Comparative efficacy of the stained blood film, counting chamber and membrane filtration technique for the diagnosis of Wuchereria bancrofti microfilaremia in untreated patients in areas of low endemicity. Southeast Asian J Trop Med Public Health 4 : 329–355.
  23. Moulia-Pelat JP, Glaziou P, Nguyen-Ngoc L, Cardines R, Spiegel A, Cartel JL, 1992. A comparative study of detection methods for evaluation of microfilaremia in lymphatic filariasis control programmes. Trop Med Parasitol 43 : 146–148.
  24. Bonnet DD, Chapman H, Kerrest J, Kessel JF, 1956. Mosquito collections and dissections for evaluating transmission of filariasis in Polynesia (Tahiti). Am J Trop Med Hyg 5 : 1093–1102.
  25. Failloux AB, Chanteau S, Chungue E, Loncke S, Sechan Y, 1991. Oral infection of Aedes polynesiensis by Wuchereria bancrofti by using parafilm membrane feeding. J Am Mosq Control Assoc 7 : 660–662.
  26. Nicolas L, Luquiaud P, Lardeux F, Mercer D, 1996. A polymerase chain reaction assay to determine infection of Aedes polynesiensis by Wuchereria bancrofti. Trans R Soc Trop Med Hyg 90 : 136–139.
  27. Casiraghi M, Anderson TJ, Bandi C, Bazzocchi C, Genchi C, 2001. A phylogenetic analysis of filarial nematodes: comparison with the phylogeny of Wolbachia endosymbionts. Parasitology 122 : 193–203.
  28. Zhou W, Rousset F, O’Neill S, 1998. Phylogeny and PCR-based classification of Wolbachia strains using wsp gene sequences. Proc R Soc Lond B Biol Sci 265 : 509–515.
  29. Ruang-Areerate T, Kittayapong P, Baimai V, O’Neill SL, 2003. Molecular phylogeny of Wolbachia endosymbionts in southeast Asian mosquitoes (Diptera: Culicidae) based on wsp gene sequences. J Med Entomol 40 : 1–5.
  30. Dean JL, Dobson SL, 2004. Characterization of Wolbachia infections and interspecific crosses of Aedes (Stegomyia) polynesiensis and Ae. (Stegomyia) riversi (Diptera: Culicidae). J Med Entomol 4 : 894–900.
  31. Werren JH, Zhang W, Guo LR, 1995. Evolution and phylogeny of Wolbachia: reproductive parasites of arthropods. Proc R Soc Lond B Biol Sci 261 : 55–71.
  32. Werren JH, Windsor DM, 2000. Wolbachia infection frequencies in insects: evidence of a global equilibrium? Proc R Soc Lond B Biol Sci 267 : 1277–1285.
  33. Kittayapong P, Baisley KJ, Baimai V, O’Neill S, 2000. Distribution and diversity of Wolbachia infections in southeast Asian mosquitoes (Diptera: Culicidae). J Med Entomol 37 : 340–345.
  34. Kittayapong P, Baimai V, O’Neill S, 2002. Field prevalence of Wolbachia in the mosquito vector Aedes albopictus. Am J Trop Med Hyg 66 : 108–111.
  35. Ricci I, Cancrini G, Gabrielli S, d’Amelio S, Favia G, 2002. Searching for Wolbachia (Rickettsiales: Rickettsiaceae) in mosquitoes (Diptera: Culicidae): Large polymerase chain reaction survey and new identifications. J Med Entomol 39 : 562–567.
  36. Rasgon JL, Scott TW, 2004. An initial survey for Wolbachia (Rickettsiales: Rickettsiaceae) infections in selected California mosquitoes (Diptera: Culicidae). J Med Entomol 41 : 255–257.
  37. Lardeux F, Cheffort J, 1996. Behavior of Wuchereria bancrofti (Filariidea: Onchocercidae) infective larvae in the vector Aedes polynesiensis (Diptera: Culicidae) in relation to parasite transmission. J Med Entomol 33 : 516–524.
  38. Pichon G, 2002. Limitation and facilitation in the vectors and other aspects of the dynamics of filarial transmission: the need for vector control against Anopheles-transmitted filariasis. Ann Trop Med Parasitol 96 : 143–152.
  39. Lardeux F, Rivière F, Sechan Y, Loncke S, 2002. Control of the Aedes vectors of the dengue viruses and Wuchereria bancrofti: the French Polynesia experience. Ann Trop Med Parasitol 96 : 105–116.
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  • Received : 17 Feb 2005
  • Accepted : 07 Mar 2005

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