1921
Volume 73, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Chagas’ disease, which is caused by the protozoan parasite , is a significant public health problem in the Americas. Its clinical presentation varies significantly in different geographic regions. Using experimental infection in mice, we studied the pathologic changes in lungs in the acute phase of the disease caused by three Mexican isolates of . Clusters of parasites and inflammatory reactions were found in the walls of conducting airways and pulmonary vessels. Inflammation was more intense in the small vessels. Although the parasites were not found in the alveolar walls, severe pathologic changes in these structure were observed and included alveolar wall thickening and inflammatory infiltration. Furthermore, serous liquid, fibrin fibers, hyaline membranes, and erythrocytes were found in the alveolar spaces. The pathomorphologic changes observed in the infected mice are consistent with pneumonitis.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2005.73.2.0730301
2005-08-01
2019-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/73/2/0730301.html?itemId=/content/journals/10.4269/ajtmh.2005.73.2.0730301&mimeType=html&fmt=ahah

References

  1. Moncayo A, 1997. Progress towards elimination of transmission of Chagas disease in Latin America. World Health Stat Q 50: 195–198. [Google Scholar]
  2. Schofield CJ, Dias JC, 1999. The Southern Cone Initiative against Chagas disease. Adv Parasitol 42: 1–27. [Google Scholar]
  3. Auger S, Storino R, Iglesias Ordoñez O, Urrutia MI, Sanmartino M, Romero D, Jörg M, 2002. Emergencies in patients with Chagas’ disease in Buenos Aires city, Argentine. Rev Soc Bras Med Trop 35: 609–616. [Google Scholar]
  4. Fuenmayor AJ, Fuenmayor AM, Carrasco H, Parada H, Fuenmayor C, Jugo D, 1997. Results of electrophysiologic studies in patients with acute Chagasic myocarditis. Clin Cardiol. 20: 1021–1024. [Google Scholar]
  5. Pinto AY, Harada GS, Valente VD, Abud JE, Gomes FD, Souza GC, Valente SA, 2001. Cardiac attacks in patients with acute Chagas disease in a family micro-outbreak, in Abaetetuba, Brazilian Amazon. Rev Soc Bras Med Trop 34: 413–419. [Google Scholar]
  6. Giglio JR, Rossi MA, 1970. Chagas’ disease pneumopathy. Chemical study of 20 cases. Hospital (Rio J) 78: 863–868. [Google Scholar]
  7. Bittencourt AL, Rodrigues de Freitas LA, Galvao de Araujo MO, Jacomo K, 1981. Pneumonitis in congenital Chagas’ disease. A study of ten cases. Am J Trop Med Hyg 30: 38–42. [Google Scholar]
  8. Ferreira MS, Borges AS, 2002. Some aspects of protozoan infections in immunocompromised patients–a review. Mem Inst Oswaldo Cruz 97: 443–457. [Google Scholar]
  9. Kirchhoff LV, 1993. American trypanosomiasis (Chagas’ disease): a tropical disease now in United States. N Engl J Med 329: 634–644. [Google Scholar]
  10. Andrade SG, Magalhães JB, Pontes AL, 1985. Evaluation of chemotherapy with benzonidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bull World Health Organ 63: 721–726. [Google Scholar]
  11. Braga MS, Lauria-Pires L, Argañaraz ER, Nascimento RJ, Teixeira ARL, 2000. Persistent infections in chronic Chagas’ disease patients treated with anti-Trypanosoma cruzi nitro-derivatives. Rev Inst Med Trop Sao Paulo 42: 157–161. [Google Scholar]
  12. Chagas C, 1909. Nova tripanosomíase humana: estudos sobre a morfologia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n.sp., ajente etiológico de nova entidade mórbida do homem. Mem Inst Oswaldo Cruz 1: 159–218. [Google Scholar]
  13. Miles MA, Cedillos RA, Povoa MM, Souza AA, Plata A, Macedo D, 1981. Do radically dissimilar Trypanosoma cruzi strains (zymodemes) cause Venezuelan and Brazilian forms of Chagas’ disease? Lancet 1: 1338–1340. [Google Scholar]
  14. Perlowagora-Szumlewicz A, Moreira CJ, 1994. In vivo differentiation of Trypanosoma cruzi. 1. Experimental evidence of the influence of vector species on metacyclogenesis. Mem Inst Oswaldo Cruz. 89: 603–618. [Google Scholar]
  15. Andersson J, Orn A, Sunnemark D, 2003. Chronic murine Chagas’ disease: the impact of host and parasite genotypes. Immunol Lett 86: 207–212. [Google Scholar]
  16. Marinho CR, Bucci DZ, Dagli ML, Bastos KR, Grisotto MG, Sardinha LR, Baptista CR, Goncalves CP, Lima MR, Alvarez JM, 2004. Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas’ disease. Infect Immun 72: 2350–2357. [Google Scholar]
  17. Andrade S, 1985. Morphological and behavioural characterization of Trypanosoma cruzi strains. Rev Soc Bras Med Trop 18: 39–46. [Google Scholar]
  18. Andrade SG, Magalhães JB, 1997. Biodemes and zymodems of Trypanosoma cruzi strains: correlations with clinical data and experimental pathology. Rev Soc Bras Med Trop 30: 27–35. [Google Scholar]
  19. de Diego JA, Palau MT, Gamallo C, Penin P, 1998. Relationship between histological findings and phylogenetic divergence in Trypanosoma cruzi. Trop Med Int Health 3: 222–233. [Google Scholar]
  20. Macedo AM, Machado CR, Oliveira RP, Pena SDJ, 2004. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas’ disease. Mem Inst Oswaldo Cruz 99: 1–12. [Google Scholar]
  21. Kirchhoff LV, 2003. Changing epidemiology and approaches to therapy for Chagas disease. Curr Infect Dis Rep 5: 59–65. [Google Scholar]
  22. Andrade LO, Machado CRS, Chiari E, Pena SDJ, Macedo AM, 1999. Different tissue distribution of diverse clones of Trypanosoma cruzi in infected mice. Mol Biochem Parasitol 100: 163–172. [Google Scholar]
  23. Guarner J, Bartlett J, Zaki SF, Colley DG, Grijalva MJ, Powell MR, 2001. Mouse model for Chagas’ disease: immunohistochemical distribution of different stages in Trypanosoma cruzi in tissue throughout infection. Am J Trop Med Hyg 65: 152–158. [Google Scholar]
  24. Vera-Cruz JM, Magallon-Gastelum E, Grihalva G, Rincón AR, Ramos-Garcia C, Armendáriz-Borunda J, 2003. Molecular diagnosis of Chagas’ disease and use of an animal model to study parasite tropism. Parasitol Res 89: 480–486. [Google Scholar]
  25. Monteon VM, Furuzawa-Carballeda J, Alejandre-Aguilar R, Aranda-Fraustro A, Rosales-Encina JL, Reyes PA, 1996. American trypanosomiasis: in situ and generalized features of parasitism and inflammation kinetics in a murine model. Exp Parasitol 83: 267–274. [Google Scholar]
  26. Zimmerman M, 1983. Ethical guideline for investigation of experimental pain in conscious animals. Pain 16: 109–110. [Google Scholar]
  27. Sadigursky M, Brodskyn CI, 1986. A new liquid medium without blood and serum for culture of hemoflagellates. Am J Trop Med Hyg. 3: 942–944. [Google Scholar]
  28. de Scorza C, Herrera L, Urdaneta-Morales S, 1996. Trypanosoma (Schizotrypanum) cruzi: histopathology in mice infected with strains isolated from Didelphis marsupialis from the valley of Caracas (Venezuela). Acta Cient Venez 47: 244–247. [Google Scholar]
  29. Bosseno MF, Barnabe C, Magallon Gastelum E, Lozano Kasten F, Ramsey J, Espinoza B, Breniere SF, 2002. Predominance of Trypanosoma cruzi lineage I in Mexico. J Clin Microbiol 40: 627–632. [Google Scholar]
  30. Brumpt E, Mazzoti L, Brumpt LC, 1939. Enquetes epidémiologiques sur la maladie de C. Chagas au mexique. Reduvidés vecteurs. Animaux réservoirs de virus. Cas humains. Ann Parasitol 17: 300–312. [Google Scholar]
  31. Coll-Cardenas R, Espinoza-Gomez F, Maldonado-Rodriguez A, Reyes-Lopez PA, Huerta-Viera M, Rojas-Larios F, 2004. Active transmission of human Chagas disease in Colima, Mexico. Mem Inst Oswaldo Cruz 99: 363–368. [Google Scholar]
  32. Tanowitz HB, Burns ER, Sinha AK, Kahn NN, Morris SA, Factor SM, Hatcher VB, Bilezikian JP, Baum SG, Wittner M, 1990. Enhanced platelet adherence and aggregation in Chagas’ disease: a potential pathogenic mechanism for cardiomyopathy. Am J Trop Med Hyg 43: 274–281. [Google Scholar]
  33. Biswas D, Choudhury A, Misra KK, 2001. Histopathology of Trypanosoma (Trypanozoon) evansi infection in bandicoot rat. I. visceral organs. Exp Parasitol 99: 148–159. [Google Scholar]
  34. Collantes-Fernandez E, Alvarez-Garcia G, Perez-Perez V, Pereira-Bueno J, Ortega-Mora LM, 2004. Characterization of pathology and parasite load in outbred and inbred mouse models of chronic Neospora caninum infection. J Parasitol 90: 579–583. [Google Scholar]
  35. Coquelin F, Boulard Y, Mora-Silvera E, Richard F, Chabaud AG, Landau I, 1999. Final stage of maturation of the erythrocytic schizonts of rodent Plasmodium in the lungs. C R Acad Sci III 322: 55–62. [Google Scholar]
  36. Meyer DJ, Allan JE, Beaman MH, 2000. Distribution of parasite stages in tissues of Toxoplasma gondii infected SCID mice and human peripheral blood lymphocyte-transplanted SCID mice. Parasite Immunol 22: 567–579. [Google Scholar]
  37. Nuñes Mdo C, Barbosa Mde M, Brum VA, Rocha MO, 2004. Morphofunctional characteristics of the right ventricle in Chagas’ dilated cardiomyopathy. Int J Cardiol 94: 79–85. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.73.2.0730301
Loading
/content/journals/10.4269/ajtmh.2005.73.2.0730301
Loading

Data & Media loading...

  • Received : 27 Aug 2004
  • Accepted : 20 Apr 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error