Volume 73, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


This report attempts to quantify the economic losses due to and in Shiqu County, Sichuan, People’s Republic of China, as well as illustrate the cost effectiveness of dog anthelmintic prophylaxis combined with a sheep and goat vaccination program in terms of disability-adjusted life years (DALYs) saved. We evaluated human losses associated with treatment costs and loss of income due to morbidity and mortality, in addition to production losses in livestock due to infection. Annual combined human and animal losses (95% confidence interval) is estimated to reach U.S.$218,676 (U.S.$189,850–247,871) if only liver-related losses in sheep, goats, and yaks are taken into account. This equates to approximately U.S.$3.47 per person annually or 1.4% of gross domestic product. However, total annual losses can be nearly U.S.$1,000,000 if additional livestock production losses are assumed. Eventual prevention of 65–95% of annual losses due to cystic echinococcosis is suggested with proposed biannual dog anthelmintic prophylaxis and a sheep and goat vaccination program. Prevention of 9–50% of human alveolar echinococcosis-associated losses is suggested based on stochastic models for the current epidemiologic situation. The median estimated cost of the program would be approximately $56,000 per year, which is a fraction of the estimated combined livestock and human financial losses due to the disease. Overall cost for the proposed control program is within the World Health Organization second most cost-effective band of less than U.S.$150 per DALY averted. However, cost per DALY averted would be less than U.S.$25 dollars for the human health sector if cost sharing was implemented between the public health and agricultural sectors based on proportional benefit from control.


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  1. Sichuan Statistical Yearbook, 2002. Beijing: China Statistics Press, 47.
  2. Budke CM, Qiu J, Wang Q, Zinsstag J, Torgerson PR, 2004. Use of disability adjusted life years in the estimation of the disease burden of echinococcosis for a high endemic region of the Tibetan plateau. Am J Trop Med Hyg 71 : 56–64. [Google Scholar]
  3. Heath DD, Jensen O, Lightowlers MW, 2003. Progress in control of hydatidosis using vaccination—a review of formulation and delivery of the vaccine and recommendations for practical use in control programmes. Acta Trop 85 : 133–143. [Google Scholar]
  4. Torgerson PR, 2003. The use of mathematical models to stimulate control options for echinococcosis. Acta Trop 85 : 211–221. [Google Scholar]
  5. Budke CM, Jiamin Q, Craig PS, Torgerson PR, 2005. Modeling the transmission of Echinococcus granulosus and Echinococcus multilocularis in dogs for a high endemic region of the Tibetan plateau. Int J Parasitol 35 : 163–170. [Google Scholar]
  6. Torgerson PR, Carmona C, Bonifacino R, 2000. Estimating the economic effects of cystic echinococcosis: Uruguay, a developing country with upper-middle income. Ann Trop Med Hyg 94 : 703–713. [Google Scholar]
  7. Torgerson PR, Dowling PM, Abo-Shehada MN, 2001. Estimating the economic effects of cystic echinococcosis. Part 3: Jordan, a developing country with lower-middle income. Ann Trop Med Hyg 95 : 595–603. [Google Scholar]
  8. World Bank, 1993. World Development Report. Investing in Health. Oxford, United Kingdom: Oxford University Press.
  9. Editorial Commission of the Shiqu County Record, 2000. Shiqu County Record 1997. Chengdu: The People’s Publication House of Sichuan Province, P.R. China.
  10. Shi D, 1997. Epidemiology and transmission of cystic echinococcosis: China. Arch Int Hidatid 32 : 50–54. [Google Scholar]
  11. Kenzhebaev SA, 1985. Pokazateli eckonomicheskovo ushererba pri eckinokokkoze karakulskikh ovets. Trudy Vsesoyuznogo Instituta Gel, mintologii-im K.L. Skyabina 28 : 62–66. [Google Scholar]
  12. Polydorou K, 1981. Animal health and economics. Case study: echinococcosis with a reference to Cyprus. Bull Off Int Epizoot 93 : 981–992. [Google Scholar]
  13. Fen-Jie L, 1993. Prevalence of Echinococcus granulosus in dogs in Xinjiang Uygur Autonomous Region, PRC. Anderson FL, ed. Compendium on Cystic Echinococcosis with Special Reference to the Xinjiang Uygur Autonomous Region, The People’s Republic of China. Provo, UT: Brigham Young University, 168–176.
  14. Deplazes P, Eckert J, 2001. Veterinary aspects of alveolar echinococcosis: a zoonosis of public health significance. Vet Parasitol 98 : 65–87. [Google Scholar]
  15. Roberts MG, Lawson JR, Gemmell MA, 1986. Population dynamics in echinococcosis and cysticercosis: mathematical model of the life-cycle of Echinococcus granulosus. Parasitology 92 : 621–641. [Google Scholar]
  16. Budke CM, Campos-Ponce M, Qian W, Torgerson PR, 2005. A canine purgation study and risk factor analysis for echinococcosis in a high endemic region of the Tibetan plateau. Vet Parasitol 127 : 49–55. [Google Scholar]
  17. Baitursinov KK, Shaikenov B, Abdybekova AM, 2004. Distribution of Echinococcus amongst agricultural animals in Kazakhstan. Torgeson PR, Shaikenov B, eds. Echinococcosis in Central Asia: Problems and Solutions. Almaty, Kazakhstan: Dauir Publishing House, 101–118.
  18. Torgerson PR, Karaeva RR, Corkeri N, Abdyjaparov TA, Kuttubaev OT, Shaikenov BS, 2003. Human cystic echinococcosis in Kyrgystan: an epidemiological study. Acta Trop 85 : 51–61. [Google Scholar]
  19. Polydorou K, 1992. Echinococcosis/Hydatidosis: The Problem and its Control Case Study Cyprus. Cyprus: Polydorou, 85–104.
  20. Xiao N, Qiu J, Nakao M, Nakaya K, Yamasaki H, Sak Y, Mamuti W, Schantz PM, Craig PS, Ito A, 2003. Indentification of Echinococcus species from yak in the Qinghai-Tibet plateau region of China. Am J Trop Med Hyg 69 : 445–446. [Google Scholar]
  21. Godot V, Harraga S, Beurton I, Deschaseaux M, Sarciron E, Gottstein B, Vuitton DA, 2000. Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile. I: Comparison of patients with progressive and abortive lesions. Clin Exp Immunol 121 : 484–490. [Google Scholar]
  22. Godot V, Harraga S, Beurton I, Tiberghien P, Sarciron E, Gottstein B, Vuitton DA, 2000. Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. II. Influence of the HLA B8, DR3, DQ2 haplotype. Clin Exp Immunol 121 : 491–498. [Google Scholar]
  23. Gottstein B, Saucy F, Deplazes P, Reichen J, Demierre G, Busato A, Zuercher C, Pugin P, 2001. Is high prevalence of Echinococcus multilocularis in wild and domestic animals associated with disease incidence in humans? Emerg Infect Dis 7 : 408–412. [Google Scholar]
  24. Rausch RL, Wilson JF, Schantz PM, 1990. A programme to reduce the risk of infection by Echinococcus multilocularis: the use of praziquantel to control the cestode in a village in the hyperendemic region of Alaska. Ann Trop Med Parasitol 84 : 239–250. [Google Scholar]
  25. Lawson JR, Roberts MG, Gemmell MA, Best SJ, 1988. Population dynamics in echinococcosis and cysticercosis: economic assessment of control strategies for Echinococcus granulosus, Taenia ovis and T. hydatigena. Parasitology 97 : 177–191. [Google Scholar]
  26. Jimenez S, Perez A, Gil H, Schantz PM, Ramalle E, Juste RA, 2002. Progress in control of cystic echinococcosis in La Rioja, Spain: decline in infection prevalences in human and animal hosts and economic costs and benefits. Acta Trop 83 : 213–221. [Google Scholar]
  27. Report of the Ad Hoc Committee on Health Research Relating to Future Intervention Options, 1996. Investing in Health Research and Development. Geneva: World Health Organization TDR/Gen, 96.1.

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  • Received : 26 Oct 2004
  • Accepted : 16 Dec 2004

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