1921
Volume 73, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4×/yr). The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2005.73.1159
2005-12-01
2017-09-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/73/6/0731159.html?itemId=/content/journals/10.4269/ajtmh.2005.73.1159&mimeType=html&fmt=ahah

References

  1. Greene BM, Taylor HR, Cupp EW, Murphy RP, White AT, Aziz MA, Schulz-Key H, D’Anna SA, Newland HS, Goldschmidt LP, Auer C, Hanson AP, Freeman SV, Reber EW, Williams PN, 1985. Controlled comparison of ivermectin and diethylcarbamazine in treatment of human onchocerciasis. N Eng J Med 313 : 133–138.
  2. Alley ES, Plaisier AP, Boatin BA, Dadzie KY, Remme J, Zerbo G, Samba EM, 1994. The impact of five years of annual ivermectin treatment on skin microfilarial loads in the onchocerciasis focus of Asubende, Ghana. Trans R Soc Trop Med Hyg 88 : 581–584.
  3. Richards F, Hopkins D, Cupp EW, 2000. Programmatic goals and approaches to onchocerciasis. Lancet 355 : 1663–1664.
  4. Duke BOL, Zea-Flores G, Castro J, Cupp EW, Munoz B, 1992. Effects of three-month doses of ivermectin on adult Onchocerca volvulus. Am J Trop Med Hyg 46 : 189–194.
  5. Gardon J, Boussinesq M, Kamgno J, Gardon-Wendel N, Demanga-Ngangue, Duke BO, 2002. Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial. Lancet 360 : 203–210.
  6. Duke BOL, Zea-Flores G, Castro J, Cupp EW, Munoz B, 1991. Comparison of the effects of a single dose and four six-monthly doses of ivermectin on adult Onchocerca volvulus. Am J Trop Med Hyg 45 : 132–137.
  7. Cupp EW, Ochoa O, Collins RC, Cupp MS, Gonzales-Peralta C, Castro J, Zea-Flores G, 1992. The effects of repetitive community-wide ivermectin treatment on transmission of Onchocerca volvulus in Guatemala. Am J Trop Med Hyg 47 : 170–180.
  8. Taylor HR, Trpis M, Cupp EW, Brotman B, Newland HS, Soboslay PT, Greene BM, 1988. Ivermectin prophylaxis against experimental Onchocerca volvulus infection in chimpanzees. Am J Trop Med Hyg 39 : 86–90.
  9. Cupp EW, Duke BO, Mackenzie CD, Rumbea Guzmán J, Vieira JC, Mendez-Galvan J, Castro J, Richards F, Sauerbrey M, Dominguez A, Eversole RR, Cupp MS, 2004. The effects of long-term community-level treatment with ivermectin (Mectizan®) on Onchocerca volvulus in Latin America. Am J Trop Med Hyg 71 : 602–607.
  10. Certification of elimination of human onchocerciasis: criteria and procedures. 2001. World Health Organization Document WHO/CDS/CPE/CEE/2001.18b. Geneva: WHO.
  11. Büttner DW, Albiez EJ, von Essen J, Erichsen J, 1988. Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique. Trop Med Parasitol 39 (Suppl 4): 390–417.
  12. Guderian RH, Anselmi M, Espinel M, Mancero T, Rivadeneira G, Proano R, Calvopina HM, Vieira JC, Cooper PJ, 1997. Successful control of onchocerciasis with community-based ivermectin distribution in the Rio Santiago focus in Ecuador. Trop Med Int Health 2 : 982–988.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.73.1159
Loading
/content/journals/10.4269/ajtmh.2005.73.1159
Loading

Data & Media loading...

  • Received : 27 Jun 2005
  • Accepted : 10 Aug 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error