Volume 73, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4×/yr). The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment.


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  • Received : 27 Jun 2005
  • Accepted : 10 Aug 2005

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