1921
Volume 73, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

This randomized, placebo-controlled trial investigated the tolerance, efficacy, and nutritional benefit of combining chemotherapeutic treatment of intestinal helminths and lymphatic filariasis. Children were infected with (30.7%), (53.4%), and hookworm (9.7%) with 69.9% having more than one of these parasites. A total of 15.8% of the children had microfilariae. Children were randomly assigned treatment with placebo, albendazole (ALB), diethylcarbamazine (DEC), or combined therapy. The combination of DEC/ALB reduced microfilarial density compared with placebo, ALB, or DEC ( ≤ 0.03). Albendazole and DEC/ALB reduced the prevalence of , and hookworm more than placebo or DEC ( ≤ 0.03). Among -infected children, those receiving ALB and DEC/ALB demonstrated greater gains in weight compared with placebo ( ≤ 0.05). Albendazole and DEC/ALB were equally efficacious in treating intestinal helminths and for children with microfilaremia, DEC/ALB was more effective than DEC, with no increase in severity of adverse reactions.

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2005-07-01
2017-11-19
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References

  1. Ottesen EA, Duke BOL, Karam M, Behbehani K, 1997. Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ 75 : 491–503.
  2. Michael E, Bundy DAP, Grenfell BT, 1996. Re-assessing the global prevalence and distribution of lymphatic filariasis. Parasitology 112 : 409–428.
  3. Chan MS, Medley GF, Jamison D, Bundy DAP, 1994. The evaluation of potential global morbidity attributable to intestinal nematode infections. Parasitology 109 : 373–387.
  4. Stephenson LS, Latham MC, Kurz KM, Kinoti SN, Brigham H, 1989. Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections. Am J Trop Med Hyg 41 : 78–87.
  5. Stephenson LS, Latham MC, Adams EJ, Kinoti SN, Pertet A, 1993. Physical fitness, growth and appetite of Kenyan schoolboys with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections are improved four months after a single dose of albendazole. J Nutr 123 : 1036–1046.
  6. Cooper ES, Duff EMW, Howell S, Bundy DAP, 1995. ‘Catch-up’ growth velocities after treatment for Trichuris dysentery syndrome. Trans R Soc Trop Med Hyg 89 : 653.
  7. Nokes C, Grantham-McGregor SM, Sawyer AW, Cooper ES, Robinson BA, Bundy DAP, 1992. Moderate to heavy infections of Trichuris trichiura affect cognitive function in Jamaican school children. Parasitology 104 : 539–547.
  8. World Health Organization, 1992. Health of School Children: Treatment of Intestinal Helminths and Schistosomiasis. Geneva: World Health Organization.
  9. Ottesen EA, Ismail MM, Horton J, 1999. The role of albendazole in programmes to eliminate lymphatic filariasis. Parasitol Today 15 : 382–386.
  10. Addiss DG, Beach MJ, Streit TG, Lutwick S, LeConte FH, Lafontant JG, Hightower AW, Lammie PJ, 1997. Randomized placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaremia in Haitian children. Lancet 350 : 480–484.
  11. Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ, 1999. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg 60 : 479–486.
  12. Dunyo SK, Nkrumah FK, Simonsen PE, 2000. Single-dose treatment of Wuchereria bancrofti infections with ivermectin and albendazole alone or in combination: evaluation of the potential for control at 12 months after treatment. Trans R Soc Trop Med Hyg 94 : 437–443.
  13. Simonsen PE, Magesa SM, Dunyo SK, Malecela-Lazaro MN, Michael E, 2004. The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania. Trans R Soc Trop Med Hyg 04 : 462–472.
  14. Belizario VY, Amarillo ME, de Leon WU, de los Reyes AE, Bugayong MG, Macatangay BJC, 2003. A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp. Bull World Health Organ 81 : 35–42.
  15. Ismail MM, Jayakody RL, 1999. Efficacy of albendazole and its combinations with ivermectin or diethylcarbamazine (DEC) in the treatment of Trichuris trichiura infections in Sri Lanka. Ann Trop Med Parasitol 93 : 501–504.
  16. Beauderochars M, Direny AD, Roberts JM, Addiss DG, Radday J, Beach MJ, Streit TG, Dardith D, Lafontant J, Lammie PJ, 2004. Community-wide reduction in prevalence and intensity of intestinal helminths as a collateral benefit of lymphatic filariasis elimination programs. Am J Trop Med Hyg 71 : 466–470.
  17. Eberhard ML, Lammie PJ, 1991. Laboratory diagnosis of filariasis. Clin Lab Med 11 : 977–1010.
  18. Lammie PJ, Hightower AW, Eberhard ML, 1994. The age-specific prevalence of antigenemia in a Wuchereria bancrofti-exposed population. Am J Trop Med Hyg 51 : 348–355.
  19. Addiss DG, Eberhard ML, Lammie PJ, McNeeley MB, Lee SH, McNeeley DF, Spencer HC, 1993. Comparative trial of clearing-dose and single high-dose ivermectin and diethylcarbamazine for treatment of lymphatic filariasis. Am J Trop Med Hyg 48 : 178–185.
  20. Dreyer G, Coutinho A, Miranda D, Noroes J, Rizzo JA, Galdino E, Rocha A, Medeiros Z, Andrade LD, Santos A, Figueredo-Silva J, Ottesen EA, 1995. Treatment of bancroftian filariasis in Recife, Brazil: A two-year comparative study of the efficacy of single treatment with ivermectin or diethylcarbamazine. Trans R Soc Trop Med Hyg 89 : 98–102.
  21. Kazura J, Greenberg J, Perry R, Weil G, Day K, Alpers M, 1993. Comparison of single-dose diethylcarbamazine and ivermectin for treatment of bancroftian filariasis in Papua New Guinea. Am J Trop Med Hyg 49 : 804–811.
  22. Chadokewitz J, 1995. Ivermectin and lymphatic filariasis: a clinical update. Parasitol Today 11 : 233–235.
  23. Richards FO, Eberhard ML, Bryan RT, McNeeley DF, Lammie PJ, McNeeley MB, Bernard Y, Hightower AW, Spencer HC, 1991. Comparison of high-dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti. Am J Trop Med Hyg 44 : 3–10.
  24. Ottesen EA, Vijayasekaran V, Vijayasekaran V, Kumaraswami V, Pillai P, Sadanandam A, Frederick S, Prabhakar R, Tripathy SP, 1990. A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis. N Engl J Med 322 : 1113–1117.
  25. Garcia LS, Bruckner DA, 1997. Diagnostic Medical Parasitology. Washington, DC: American Society for Microbiology Press.
  26. World Health Organization, 1981. Field Studies on the Relation between Intestinal Infections and Human Nutrition. Geneva: World Health Organization. (NUT/81.3 PDP/82.4).
  27. World Health Organization, 1987. Prevention and control of intestinal parasitic infections. World Health Organ Tech Rep Ser 749 : 1–86.
  28. Zar JH, 1974. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, Inc.
  29. Sato Y, Kobayashi J, Toma H, Shiroma Y, 1995. Efficacy of stool examination for detection of Strongyloides infection. Am J Trop Med Hyg 53 : 248–250.
  30. Dunyo SK, Nkrumah FK, Simonsen PE, 2000. A randomized double-blind placebo-controlled field trial of ivermectin and albendazole alone and in combination for the treatment of lymphatic filariasis in Ghana. Trans R Soc Trop Med Hyg 94 : 205–211.
  31. Pani SP, Reddy GS, Das LK, Vanamail P, Hoti SL, Ramesh J, 2002. Tolerability and efficacy of single dose albendazole, diethylcarbamazine citrate (DEC) or co-administration of albendazole with DEC in the clearance of Wuchereria bancrofti in asymptomatic microfilaraemic volunteers in Pondicherry, south India: a hospital-base study. Filarial J 1 : 1.
  32. Dreyer G, Noroes J, Addiss D, Santos A, Medeiros Z, Figueredo-Silva J, 1999. Bancroftian filariasis in a paediatric population: an ultrasonographic study. Trans R Soc Trop Med Hyg 93 : 633–636.
  33. Fox LM, Furness BW, Haser JK, Brissau JM, Louis-Charles J, Wilson SF, Addiss DG, Lammie PJ, Beach MJ, 2005. Ultra-sonographic examination of Haitian children with lymphatic filariasis: a longitudinal assessment in the context of antifilarial drug treatment. Am J Trop Med Hyg 72 : 642–648.
  34. Jayakody RL, De Silva CS, Weerasinghe WM, 1993. Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions. Trop Biomed 10 : 19–24.
  35. Cao W, van der Ploeg CPB, Plaisier AP, van der Sluijs IJ, Habbema JDF, 1997. Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment. Trop Med Int Health 2 : 393–403.
  36. Ismail MM, Jayakody RL, Weil GJ, Fernando D, de Silva MSG, de Silva GAC, Balasooriya WK, 2001. Long-term efficacy of single-dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis. Trans R Soc Trop Med Hyg 95 : 332–335.
  37. Dreyer G, Coutinho A, Miranda D, Noroes J, Rizzo JA, Galdino E, Rocha A, Medeiros Z, Andrade LD, Santos A, Figueredo-Silva J, Ottesen EA, 1995. Treatment of bancroftian filariasis in Recife, Brazil: a two-year comparative study of the efficacy of single treatments with ivermectin or diethylcarbamazine. Trans R Soc Trop Med Hyg 89 : 98–102.
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  • Received : 18 Aug 2004
  • Accepted : 02 Feb 2005

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