Volume 73, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


This randomized, placebo-controlled trial investigated the tolerance, efficacy, and nutritional benefit of combining chemotherapeutic treatment of intestinal helminths and lymphatic filariasis. Children were infected with (30.7%), (53.4%), and hookworm (9.7%) with 69.9% having more than one of these parasites. A total of 15.8% of the children had microfilariae. Children were randomly assigned treatment with placebo, albendazole (ALB), diethylcarbamazine (DEC), or combined therapy. The combination of DEC/ALB reduced microfilarial density compared with placebo, ALB, or DEC ( ≤ 0.03). Albendazole and DEC/ALB reduced the prevalence of , and hookworm more than placebo or DEC ( ≤ 0.03). Among -infected children, those receiving ALB and DEC/ALB demonstrated greater gains in weight compared with placebo ( ≤ 0.05). Albendazole and DEC/ALB were equally efficacious in treating intestinal helminths and for children with microfilaremia, DEC/ALB was more effective than DEC, with no increase in severity of adverse reactions.


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  • Received : 18 Aug 2004
  • Accepted : 02 Feb 2005

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