Volume 73, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


What is currently known about the ecology of North American hantaviruses has come largely from studies on Sin Nombre virus (SNV). We conducted a longitudinal study of Bayou virus (BAYV), the second-leading agent of hantavirus pulmonary syndrome in the United States. Antibodies to hantavirus were detected from (most commonly infected species), , , , and . However, only had viral RNA in tissues and excreta, suggesting that antibodies detected in other species may have resulted from spill-over infection. Seroprevalence rates averaged around 16% for and varied seasonally. The heaviest males exhibited the highest levels of seroprevalence. Seroprevalence was higher in coastal prairie (20.0%) than old-fields (10.5%) and was associated with host abundance. These patterns are similar to those of SNV and can be used in identification of potentially at-risk areas.


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  1. Lee HW, van der Groen G, 1989. Hemorrhagic fever with renal syndrome. Prog Med Virol 36 : 92–102. [Google Scholar]
  2. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917. [Google Scholar]
  3. Schmaljohn C, Hjelle B, 1997. Hantaviruses: a global disease problem. Emerg Infect Dis 3 : 95–104. [Google Scholar]
  4. Tsai TF, 1987. Hemorraghic fever with renal syndrome—mode of transmission to humans. Lab Anim Sci 37 : 428–430. [Google Scholar]
  5. Glass GE, Childs JE, Korch GW, LeDuc JW, 1988. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect 101 : 459–472. [Google Scholar]
  6. Umenai T, Watanabe M, Sekino H, Yokoyama S, Kaubragi T, Takahashi K, Lee HW, Ishida N, 1981. Korean hemorraghic fever among rural residents in Japan. J Infect Dis 144 : 460–463. [Google Scholar]
  7. Mills JN, Ksiazek TG, Peters CJ, Childs JE, 1999. Long-term studies of hantavirus reservoir populations in the southwestern United States: a synthesis. Emerg Infect Dis 5 : 135–142. [Google Scholar]
  8. Hjelle B, Goade D, Torrez-Martinez N, Lang-Williams M, Kim J, Harris RL, Rawlings JA, 1996. Hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by Bayou hantavirus. Clin Inf Dis 23 : 495–500. [Google Scholar]
  9. Ksiazek TG, Nichol ST, Mills JN, Groves MG, Wozniak A, McAdams S, Monroe MC, Johnson AM, Martin ML, Peters CJ, Rollin PE, 1997. Isolation, genetic diversity, and geographic distribution of Bayou virus (Bunyaviridae: Hantavirus). Am J Trop Med Hyg 57 : 445–448. [Google Scholar]
  10. Torrez-Martinez N, Bharadwaj M, Goade D, Delury J, Moran P, Hicks B, Nix B, Davis JL, Hjelle B, 1998. Bayou virus-associated Hantavirus Pulmonary Syndrome in eastern Texas: identification of the rice rat, Oryzomys palustris, as reservoir host. Emerg Infect Dis 4 : 105–111. [Google Scholar]
  11. Nisbett RA, Caire W, Stuart MD, Caddell GM, Crutcher JM, Calisher CH, 2001. Serologic survey of Oklahoma rodents: evidence for the presence of a hantavirus and an arenavirus. Proc Okla Acad Sci 81 : 53–66. [Google Scholar]
  12. Abbott KD, Ksiazek TG, Mills JN, 1999. Long-term hantavirus persistence in rodent populations in central Arizona. Emerg Infect Dis 5 : 102–112. [Google Scholar]
  13. Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW, Porter R, Bryan RT, 1999. Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners Region, United States. Emerg Infect Dis 5 : 87–94. [Google Scholar]
  14. Root JJ, Calisher CH, Beaty BJ, 1999. Relationships of deer mouse movement, vegetative structure, and prevalence of infection with Sin Nombre virus. J Wildl Dis 35 : 311–318. [Google Scholar]
  15. Boone JD, McGwire KC, Otteson EW, DeBaca RS, Kuhn EA, Villard P, Brussard PF, St Jeor SC, 2000. Remote sensing and geographic information systems: charting Sin Nombre virus infections in deer mice. Emerg Inf Dis 6 : 248–258. [Google Scholar]
  16. Biggs JR, Bennett KD, Mullen MA, Haarmann TK, Salisbury M, Robinson RJ, Keller D, Torrez-Martinez N, Hjelle B, 2000. Relationship of ecological variables to Sin Nombre virus antibody seroprevalence in populations of deer mice. J Mammal 81 : 676–682. [Google Scholar]
  17. Glass GE, Cheek JE, Patz JA, Shields TM, Doyle TJ, Thoroughman DA, Hunt DK, Enscore RE, Gage KL, Irland C, Peters CJ, Bryan R, 2000. Using remotely sensed data to identify areas at risk for hantavirus pulmonary syndrome. Emerg Inf Dis 6 : 238–247. [Google Scholar]
  18. Yates TL, Mills JN, Parmenter CA, Ksiazek TG, Parmenter RR, Vande Castle JR, Calisher CH, Nichol ST, Abbott KD, Young JC, Morrison ML, Beaty BJ, Dunnum JL, Baker RJ, Salazar-Bravo J, Peters CJ, 2002. The ecology and evolutionary history of an emergent disease: hantavirus pulmonary syndrome. BioScience 52 : 989–998. [Google Scholar]
  19. Calisher CH, Sweeney W, Mills JN, Beaty BJ, 1999. Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis 5 : 126–134. [Google Scholar]
  20. Kuenzi AJ, Morrison ML, Swann DE, Hardy PC, Downard GT, 1999. A longitudinal study of Sin Nombre virus prevalence in rodents, southeastern Arizona. Emerg Infect Dis 5 : 113–117. [Google Scholar]
  21. Langlois JP, Fahrig L, Merriam G, Artsob H, 2001. Landscape structure influences continental distribution of hantavirus in deer mice. Landsc Ecol 16 : 255–266. [Google Scholar]
  22. Boone JD, McGwire KC, Otteson EW, DeBaca RS, Kuhn EA, St. Jeor SC, 2002. Infection dynamics of Sin Nombre virus after a widespread decline in host populations. Am J Trop Med Hyg 67 : 310–318. [Google Scholar]
  23. Mantooth SJ, Milazzo ML, Bradley RD, Hice CL, Ceballos G, Tesh RB, Fulhorst CF, 2001. Geographical distribution of rodent-associated hantaviruses in Texas. J Vector Ecol 26 : 7–14. [Google Scholar]
  24. Chu YK, Rossi C, Leduc JW, Lee HW, Schmaljohn CS, Dalrymple JM, 1994. Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae. Virology 198 : 196–204. [Google Scholar]
  25. Chu YK, Owen RD, Gonzalez LM, Jonsson CB, 2003. The complex ecology of hantavirus in Paraguay. Am J Trop Med Hyg 69 : 263–268. [Google Scholar]
  26. Rotenberry JT, Wiens JA, 1980. Habitat structure, patchiness, and avian communities in North American steppe vegetation: a multivariate analysis. Ecology 61 : 1228–1250. [Google Scholar]
  27. Adler GH, Wilson ML, 1987. Demography of a habitat generalist, the white-footed mouse, in a heterogeneous environment. Ecology 68 : 1785–1796. [Google Scholar]
  28. Bullock J, 1996. Plants. Sutherland WJ, ed. Ecological Census Techniques: A Handbook. Cambridge: Cambridge University Press, 111–138.
  29. Bellows AS, Pagels JF, Mitchell JC, 2001. Macrohabitat and microhabitat affinities of small mammals in a fragmented landscape on the upper Coastal Plain of Virginia. Am Midl Nat 146 : 345–360. [Google Scholar]
  30. SAS Institute, 1999. SAT/STAT user’s guide (ver. 8.2). Cary, NC: SAS Institute Inc.
  31. Lee HW, Lee PW, Baek LJ, Song CK, Seong IW, 1981. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorraghic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30 : 1106–1112. [Google Scholar]
  32. Hutchinson KL, Rollin PE, Peters CJ, 1998. Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg 59 : 58–65. [Google Scholar]
  33. Mills JN, Ksiazek TG, Ellis BA, Rollin PE, Nichol ST, Yates TL, Gannon WL, Levy CE, Engelthaler DM, Davis T, Tandra DT, Frampton JW, Nichols CR, Peters CJ, Childs JE, 1997. Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg 56 : 273–284. [Google Scholar]
  34. Botten J, Mirowsky K, Kusewitt D, Ye CY, Gottlieb K, Prescott J, Hjelle B, 2003. Persistent Sin Nombre virus infection in the deer mouse (Peromyscus maniculatus) model: sites of replication and strand-specific expression. J Virol 77 : 1540–1550. [Google Scholar]
  35. Hutchinson KL, Rollin PE, Shieh WJ, Zaki S, Greer PW, Peters CJ, 2000. Transmission of Black Creek Canal virus between cotton rats. J Med Virol 60 : 70–76. [Google Scholar]
  36. Mackelprang R, Dearing MD, St Jeor S, 2001. High prevalence of Sin Nombre virus in rodent populations, central Utah: a consequence of human disturbance? Emerg Infect Dis 7 : 480–482. [Google Scholar]
  37. Grenfell BT, Harwood J, 1997. Metapopulation dynamics of infectious diseases. Trends Ecol Evol 12 : 395–399. [Google Scholar]
  38. Meade MS, Florin JW, Gesle WM, 1988. Medical Geography. New York: Guilford Press.

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  • Received : 12 Apr 2005
  • Accepted : 13 Jun 2005

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