Volume 73, Issue 5_suppl
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


This study describes a successful sporozoite infection in . Twenty-eight naive or previously infected monkeys, either splenectomized or spleen intact, were inoculated intravenously or subcutaneously with sporozoites of the Salvador I strain or with two wild isolates (VCC-4 and VCC-5; -ali-olombia). The monkeys were successfully infected regardless of the parasite strain, spleen presence, or inoculation route and showed prepatent periods that ranged from 16 to 89 days. Only one monkey inoculated intravenously failed to develop parasitemia. Since immune protection against malaria pre-erythrocytic forms is mediated by both helper and cytolytic T cells that may home in the spleen and cultures are not yet available; the use of spleen-intact , susceptible to both adapted and non-adapted strains of sporozoites, is a valuable model for evaluation of pre-erythrocytic vaccine candidates.


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  • Received : 12 Apr 2005
  • Accepted : 07 Jun 2005

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