Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Isolates cases and groups of patients co-infected with human T cell lymphotropic virus type I (HTLV-I) and Norwegian scabies have been previously reported. Peru is considered to be endemic for HTLV-I. Between June 1999 and December 2000, 23 patients with Norwegian scabies were enrolled in this study after written informed consent was obtained. Antibodies against HTLV-I were detected by an enzyme-linked immunosorbent assay and confirmatory Western blot. Patients ranged in age from 3 months to 84 years; 15 (65.2%) were female. Infection with HTLV-I was found in 16 (69.6%) patients. Comorbid features included corticosteroid therapy (8.6%), malnutrition (8.6%), and Down’s syndrome (4.3%). Among those who consented to be tested for human immunodeficiency virus (n = 13, 56.5%), no one had a positive result. The three patients that reported one or more prior episodes of Norwegian scabies were infected with HTLV-I and two of these HTLV-I-positive patients died. Infection with HTLV-I is an important co-factor related to Norwegian scabies in Peru. In our setting, the evaluation for HTLV-I in all Norwegian scabies cases is highly recommended, especially when no other risk factors are apparent.


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  1. Burstein Z, 1963. Sarna Noruega en el Perú. Actas finales del V Congreso Ibero Latinoamericano de Dermatología. Buenos Aires, Argentina, 1277–1282.
  2. Donabedian H, Khasan V, 1992. Norwegian scabies in patients with AIDS. Clin Infect Dis 14 : 162–164. [Google Scholar]
  3. Paterson W, Allen B, Beveridge G, 1973. Norwegian scabies during immunosuppressive therapy. BMJ 4 : 211–212. [Google Scholar]
  4. Clayton R, Farrow S, 1975. Norwegian scabies following topical steroid therapy. Postgrad Med J 51 : 657–659. [Google Scholar]
  5. Logan J, 1967. Norwegian scabies and lymphatic leukemia. Br J Dermatol 79 : 303–305. [Google Scholar]
  6. Schlesinger I, Oerlich D, Tyrring S, 1994. Crusted (Norwegian) scabies in patients with AIDS: the range of clinical presentations. South Med J 87 : 352–356. [Google Scholar]
  7. Hubler W, Clabaugh W, 1976. Epidemic Norwegian scabies. Arch Dermatol 112 : 179–181. [Google Scholar]
  8. Barbosa Jr. A, Silva TM, Santos MI, Garrido F, Patel BN, Cavalcanti M, Riccio MC, 1996. Coexistence of an unusual form of scabies and lepromatous leprosy. A case report. Pathol Res Pract 192 : 91–93. [Google Scholar]
  9. Yarbrough G, Iriondo M, 1987. Diabetic patient with crusted plaques. Crusted (Norwegian) scabies. Arch Dermatol 123 : 811–814. [Google Scholar]
  10. Dick G, Burgdorf W, Gentry W, 1979. Norwegian scabies in Bloom’s Syndrome. Arch Dermatol 115 : 212–213. [Google Scholar]
  11. Espy P, Jolly H, 1976. Norwegian scabies. Arch Dermatol 112 : 193–196. [Google Scholar]
  12. Poiesz BJ, Ruscetti FW, Gadzar AF, Bunn PA, Minna JD, Gallo RC, 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma. Proc Natl Acad Sci USA 77 : 7415–7419. [Google Scholar]
  13. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, de The G, 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2 : 407–410. [Google Scholar]
  14. Gotuzzo E, Terashima A, Alvarez H, Tello R, Infante R, Watts DM, Freedman DO, 1999. Strongyloides stercoralis hyperinfection associated with human T cell lymphotropic virus type-I infection in Peru. Am J Trop Med Hyg 60 : 146–149. [Google Scholar]
  15. Nakao K, Ohba N, Matsumoto M, 1989. Noninfectious anterior uveitis in patients infected with human T-lymphotropic virus type I. Jpn J Ophthalmol 33 : 472–481. [Google Scholar]
  16. Daisley H, Charles W, Suite M, 1993. Crusted (Norwegian) scabies as a prediagnostic indicator for HTLV-I infection. Trans R Soc Trop Med Hyg 87 : 295. [Google Scholar]
  17. del Guidice P, Sainte Marie D, Gerard Y, Couppie P, Pradinaud R, 1997. Is crusted (Norwegian) scabies a marker of adult T cell/leukemia lymphoma in human T lymphotrophic virus type I–seropositive patients? J Infect Dis 176 : 1090–1092. [Google Scholar]
  18. Zurita S, Costa C, Watts D, Indacochea S, Campos P, Sanchez J, Gotuzzo E, 1997. Prevalence of human retroviral infection in Quillabamba and Cuzco, Peru: a new endemic area for human T-cell lymphotropic virus type 1. Am J Trop Med Hyg 56 : 561–565. [Google Scholar]
  19. Sanchez-Palacios C, Gotuzzo E, Vandamme AM, Maldonado Y, 2003. Seroprevalence and risk factors for human T-cell lymphotropic virus (HTLV-I) infection among ethnically and geographically diverse Peruvian women. Int J Infect Dis 7 : 132–134. [Google Scholar]
  20. García L, Bruckner D, 1997. Diagnostic Medical Parasitology. Third edition. Washington, DC: American Society for Microbiology Press, 548–553.
  21. Ndiaye B, Develoux M, Dieng M, 1999. Crusted (Norwegian) scabies in Dakar (Senegal). Sante 9 : 243–248. [Google Scholar]
  22. Terra L, Pelicano S, 1996. Norwegian scabies in immunosuppressed patients. Report of a case. Minerva Med 87 : 423–425. [Google Scholar]
  23. Camassa F, Fania M, Ditano G, Silvestris AM, Lomuto M, 1995. Neonatal scabies. Cutis 56 : 210–212. [Google Scholar]
  24. Andersen B, Haugen H, Rasch M, Heldal H, Tageson A, 2000. Outbreak of scabies in Norwegian nursing homes and home care patients: control and prevention. J Hosp Infect 45 : 160–164. [Google Scholar]
  25. Suzumiya J, Sumiyoshi A, Kuroki Y, Inoue S, 1992. Crusted (Norwegian) scabies with adult T-cell leukemia. Br J Dermatol 127 : 57–59. [Google Scholar]
  26. Bergman J, Dodd W, Trotter M, Oger J, Dutz J, 1999. Crusted scabies in association with human T cell lymphotropic virus 1. J Cutan Med Surg 3 : 148–152. [Google Scholar]
  27. Brites C, Weyll M, Pedroso C, Badaro R, 2002. Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infections in Bahia, Brazil. AIDS 16 : 1292–1293. [Google Scholar]

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  • Received : 15 Sep 2004
  • Accepted : 25 Nov 2004

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