1921
Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

taeniasis/cysticercosis is a zoonotic disease complex in which the pig is an obligate intermediate host. The infection is widespread, particularly in the developing world, and neurocysticercosis is a major cause of human neurologic disease where the parasite is endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control disease transmission. We have investigated a vaccine strategy to prevent parasite infection of the pig intermediate host. Such a strategy would interrupt the parasite’s life cycle and eliminate the source of infection for humans. Two recombinant antigens selected from the parasite oncosphere life cycle stage were tested in vaccination trials in pigs that were challenged orally with eggs. Both antigens were highly effective in protecting the pigs against infection with the parasite (98.6% and 99.9% protection, respectively). No viable cysts were found in eight pigs vaccinated with one of the antigens. A recombinant subunit vaccine based on oncosphere antigens has the potential to improve the available control measures for and thereby reduce or eliminate neurocysticercosis.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2005.72.837
2005-06-01
2017-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/72/6/0720837.html?itemId=/content/journals/10.4269/ajtmh.2005.72.837&mimeType=html&fmt=ahah

References

  1. Garcia HH, Gonzalez AE, Evans CA, Gilman RH, 2003. Cysticercosis Working Group in Peru. Taenia solium cysticercosis. Lancet 362 : 547–556.
  2. Schantz PM, Tsang VC, 2003. The US Centers for Disease Control and Prevention (CDC) and research and control of cysticercosis. Acta Trop 87 : 161–163.
  3. Schantz PM, Cruz M, Sarti E, Pawlowski Z, 1993. Potential eradicability of taeniasis and cysticercosis. Bull Pan Am Health Organ 27 : 397–403.
  4. Flisser A, Gauci CG, Zoli A, Martinez-Ocana J, Garza-Rodriguez A, Dominguez-Alpizar JL, Maravilla P, Rodriguez-Canul R, Avila G, Aguilar-Vega L, Kyngdon C, Geerts S, Lightowlers MW, 2004. Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infect Immun 72 : 5292–5297.
  5. Patak KML, Gaur SNS, 1990. Immunization of pigs with culture antigens of Taenia solium. Vet Parasitol 34 : 353–357.
  6. Verastegui M, Gilman RH, Gonzales A, Garcia HH, Gavidia C, Falcon N, Bernal T, Arana Y, Tsang VC, 2002. Cysticercosis Working Group In Peru. Taenia solium oncosphere antigens induce immunity in pigs against experimental cysticercosis. Vet Parasitol 108 : 49–62.
  7. Lightowlers MW, Colebrook AL, Gauci CG, Gauci SM, Kyngdon CT, Monkhouse JL, Vallejo Rodriquez C, Read AJ, Rolfe RA, Sato C, 2003. Vaccination against cestode parasites: antihelminth vaccines that work and why. Vet Parasitol 115 : 83–123.
  8. Gauci CG, Flisser A, Lightowlers MW, 1998. A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens. Int J Parasitol 28 : 757–760.
  9. Gauci CG, Lightowlers MW, 2001. Alternative splicing and sequence diversity of transcripts from the oncosphere stage of Taenia solium with homology to the 45W antigen of Taenia ovis. Mol Biochem Parasitol 112 : 173–181.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.72.837
Loading
/content/journals/10.4269/ajtmh.2005.72.837
Loading

Data & Media loading...

  • Received : 14 Sep 2004
  • Accepted : 29 Nov 2004

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error