1921
Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The literature contains few longitudinal studies that have assessed areas endemic for canine leishmaniasis and over the same time interval -specific cellular and humoral immunity in healthy dogs. Fourteen dogs, three mixed breed and 11 Ibizian hounds, living in an area of Spain that was highly endemic for leishmaniasis were followed-up over a three-year period by serologic analysis and the leishmanin skin test (LST). All but one of these dogs remained clinically healthy during the study period. Seroconversion was observed in four dogs. The three mixed breed dogs had a negative reaction in the LST in the first and third years. The general trend in the Ibizian hounds was an increase in the diameter of the LST reaction at both the 48- and 72-hour readings in the third year. This study demonstrates that in addition to an increase in -specific humoral immune response in Ibizian hounds, a parallel increase in cellular immune response was observed.

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References

  1. Pinelli E, Killick Kendrick R, Wagenaar J, Bernadina W, del Real G, Ruitenberg J, 1994. Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infect Immun 62 : 229–235. [Google Scholar]
  2. Cabral M, O’Grady JE, Gomes S, Sousa JC, Thompson H, Alexander J, 1998. The immunology of canine leishmaniosis: strong evidence for a developing disease spectrum from asymptomatic dogs. Vet Parasitol 76 : 173–180. [Google Scholar]
  3. Meller Melloul C, Farnarier C, Dunan S, Faugere B, Franck J, Mary C, Bongrand P, Quilici M, Kaplanski S, 1991. Evidence of subjects sensitized to Leishmania infantum on the French Mediterranean coast: differences in gamma interferon production between this population and visceral leishmaniasis patients. Parasite Immunol 13 : 531–536. [Google Scholar]
  4. Marty P, Le Fichoux Y, Giordana D, Brugnetti A, 1992. Leishmanin reaction in the human population of a highly endemic focus of canine leishmaniasis in Alpes-Maritimes, France. Trans R Soc Trop Med Hyg 86 : 249–250. [Google Scholar]
  5. Mary C, Auriault V, Faugere B, Dessein AJ, 1999. Control of Leishmania infantum infection is associated with CD8(+) and gamma interferon- and interleukin-5-producing CD4(+) antigen-specific T cells. Infect Immun 67 : 5559–5566. [Google Scholar]
  6. Pinelli E, Gonzalo RM, Boog CJ, Rutten VP, Gebhard D, del Real G, Ruitenberg EJ, 1995. Leishmania infantum-specific T cell lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner. Eur J Immunol 25 : 1594–1600. [Google Scholar]
  7. Cardoso L, Neto F, Sousa JC, Rodrigues M, Cabral M, 1998. Use of a leishmanin skin test in the detection of canine Leishmania-specific cellular immunity. Vet Parasitol 79 : 213–220. [Google Scholar]
  8. Solano-Gallego L, Llull J, Ramos G, Riera C, Arboix M, Alberola J, Ferrer L, 2000. The Ibizian hound presents a predominantly cellular immune response against natural Leishmania infection. Vet Parasitol 90 : 37–45. [Google Scholar]
  9. Carrera L, Fermin ML, Tesouro M, Garcia P, Rollan E, Gonzalez JL, Mendez S, Cuquerella M, Alunda JM, 1996. Antibody response in dogs experimentally infected with Leishmania infantum: infection course antigen markers. Exp Parasitol 82 : 139–146. [Google Scholar]
  10. Fisa R, Gallego M, Castillejo S, Aisa MJ, Serra T, Riera C, Carrio J, Gallego J, Portus M, 1999. Epidemiology of canine leishmaniosis in Catalonia (Spain) the example of the Priorat focus. Vet Parasitol 83 : 87–97. [Google Scholar]
  11. Zaffaroni E, Rubaudo L, Lanfranchi P, Mignone W, 1999. Epidemiological patterns of canine leishmaniosis in western Liguria (Italy). Vet Parasitol 81 : 11–19. [Google Scholar]
  12. Solano-Gallego L, Morell P, Arboix M, Alberola J, Ferrer L, 2001. Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology. J Clin Microbiol 39 : 560–563. [Google Scholar]
  13. da Silva VO, Borja Cabrera GP, Correia Pontes NN, de Souza EP, Luz KG, Palatnik M, Palatnik de Sousa CB, 2000. A phase III trial of efficacy of the FML-vaccine against canine kalaazar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN). Vaccine 19 : 1082–1092. [Google Scholar]
  14. Borja Cabrera GP, Correia Pontes NN, da Silva VO, Paraguai de Souza E, Santos WR, Gomes EM, Luz KG, Palatnik M, Palatnik de Sousa CB, 2002. Long lasting protection against canine kalaazar using the FML-QuilA saponin vaccine in an endemic area of Brazil (Sao Goncalo do Amarante, RN). Vaccine 20 : 3277–3284. [Google Scholar]
  15. Riera C, Valladares JE, Gallego M, Aisa MJ, Castillejo S, Fisa R, Ribas N, Carrio J, Alberola J, Arboix M, 1999. Serological and parasitological follow-up in dogs experimentally infected with Leishmania infantum and treated with meglumine antimoniate. Vet Parasitol 84 : 33–47. [Google Scholar]
  16. Aebischer T, Moody S, Handman E, 1993. Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect Immun 61 : 220–226. [Google Scholar]
  17. Bogdan C, Gessner A, Werner S, Rollinghoff M, 1996. Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol 8 : 517–525. [Google Scholar]
  18. Bogdan C, Rollinghoff M, 1998. The immune response to Leishmania: mechanisms of parasite control and evasion. Int J Parasitol 28 : 121–134. [Google Scholar]
  19. Moreno J, Alvar J, 2002. Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol 18 : 399–405. [Google Scholar]
  20. Quinnell RJ, Courtenay O, Garcez LM, Kaye PM, Shaw MA, Dye C, Day MJ, 2003. IgG subclass responses in a longitudinal study of canine visceral leishmaniasis. Vet Immunol Immunopathol 91 : 161–168. [Google Scholar]
  21. Breitschwerdt EB, Levy MG, Davidson MG, Walker DH, Burgdorfer W, Curtis BC, Babineau CA, 1990. Kinetics of IgM and IgG responses to experimental and naturally acquired Rickettsia rickettsii infection in dogs. Am J Vet Res 51 : 1312–1316. [Google Scholar]
  22. Rimmelzwaan GF, Groen J, Egberink H, Borst GH, Uytdehaag FG, Osterhaus AD, 1991. The use of enzyme-linked immunosorbent assay systems for serology and antigen detection in parvovirus, coronavirus and rotavirus infections in dogs in The Netherlands. Vet Microbiol 26 : 25–40. [Google Scholar]
  23. Kerr AA, Denton RG, 1978. Delayed skin hypersensitivity reaction in normal children. N Z Med J 88 : 57–59. [Google Scholar]
  24. Kniker WT, Anderson CT, McBryde JL, Roumiantzeff M, Lesourd B, 1984. Multitest CMI for standardized measurement of delayed cutaneous hypersensitivity and cell-mediated immunity. Normal values and proposed scoring system for healthy adults in the U.S.A. Ann Allergy 52 : 75–82. [Google Scholar]
  25. Corriel RN, Kniker WT, McBryde JL, Lesourd BM, 1985. Cell-mediated immunity in schoolchildren assessed by multitest skin testing. Normal values and proposed scoring system for healthy children. Am J Dis Child 139 : 141–146. [Google Scholar]
  26. Bardare M, Armenio L, Businco L, Cavagni G, de Martino M, Duse M, Masi M, Monafo V, Pietrogrande MC, Tovo P, Venturi MC, 1990. Screening for delayed-hypersensitivity in Italian children: multicentric study by multitest skin testing. Eur J Pediatr 150 : 37–39. [Google Scholar]
  27. Aisa MJ, Castillejo S, Gallego M, Fisa R, Riera MC, de Colmenares M, Torras S, Roura X, Sentis J, Portus M, 1998. Diagnostic potential of Western blot analysis of sera from dogs with leishmaniasis in endemic areas and significance of the pattern. Am J Trop Med Hyg 58 : 154–159. [Google Scholar]
  28. Ferrer L, Solano-Gallego L, Arboix M, Alberola J, 2003. Evaluation of the specific immune response in dogs infected by Leishmania infantum. Thoday KL, Foil CS, Bond R, eds. Advances in Veterinary Dermatology. Oxford, United Kingdom: Blackwell Publishing, 92–99.
  29. Nascimento MD, Alcantara Neves NM, Muniz ME, Nunes SF, Paranhos M, de Carvalho LC, 1993. Induction and modulation of the immune response to Leishmania by Montenegro’s skin test. Trans R Soc Trop Med Hyg 87 : 91–93. [Google Scholar]
  30. Jose FF, da Silva IM, Araujo MI, Almeida RP, Bacellar O, Carvalho EM, 2001. Evaluation of the sensitization power of Montenegro skin test. Rev Soc Bras Med Trop 34 : 537–542. [Google Scholar]
  31. Weigle KA, Valderrama L, Arias AL, Santrich C, Saravia NG, 1991. Leishmanin skin test standardization and evaluation of safety, dose, storage, longevity of reaction and sensitization. Am J Trop Med Hyg 44 : 260–271. [Google Scholar]
  32. Satti I, el Hassan A, Khalil el T, Akuffo H, 2002. The effect of repeated leishmanin skin testing on the immune responses to Leishmania antigen in healthy volunteers. Trans R Soc Trop Med Hyg 96 : 565–567. [Google Scholar]
  33. Keenan CM, Hendricks LD, Lightner L, Johnson AJ, 1984. Visceral leishmaniasis in the German shepherd dog. II. Pathology. Vet Pathol 21 : 80–86. [Google Scholar]
  34. Martinez Subiela S, Tecles F, Eckersall PD, Ceron JJ, 2002. Serum concentrations of acute phase proteins in dogs with leishmaniasis. Vet Rec 150 : 241–244. [Google Scholar]
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  • Received : 02 Feb 2004
  • Accepted : 13 Oct 2004

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