Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Hantavirus pulmonary syndrome (HPS) is an emerging disease caused by an increasing number of distinct hantavirus serotypes found worldwide. It is also a very severe immune disease. It progresses quickly and is associated with a high mortality rate. At the prodrome phase, hantavirosis symptoms can resemble those of other infectious diseases such as leptospirosis and influenza. Thus, prognosis could be improved by developing a rapid and sensitive diagnostic test for hantavirus infection, and by improving knowledge about clinical aspects of this disease. This study describes clinical features and laboratory parameters throughout the course of HPS in 98 patients. We report the seasonality and regional distribution of this disease in Paraná State, Brazil during the last seven years. In addition, we evaluated a specific molecular diagnostic test based on a nested reverse transcriptase-polymerase chain reaction for the detection of hantaviruses circulating in Brazil.


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  1. Lopez N, Padula P, Rossi C, Lazaro EM, Franze-Fernandez MT, 1996. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220 : 223–226. [Google Scholar]
  2. Peters CJ, Khan AS, 2002. Hantavirus pulmonary syndrome: the new American hemorrhagic fever. Clin Infect Dis 34 : 1224–1231. [Google Scholar]
  3. Lednicky JA, 2003. Hantaviruses: a short review. Arch Pathol Lab Med 127 : 30–35. [Google Scholar]
  4. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917. [Google Scholar]
  5. Levis S, Morzunov SP, Rowe JE, 1998. Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177 : 529–538. [Google Scholar]
  6. Galeno H, Mora J, Villagra E, Fernandez J, Hernandez J, Mertz GJ, Ramirez E, 2002. First human isolate of hantavirus (Andes virus) in the Americas. Emerg Infect Dis 8 : 657–660. [Google Scholar]
  7. Feldmann H, Sanchez A, Morzunov S, Spiropolou CF, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1993. Utilization of autopsy for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus pulmonary syndrome. Virus Res 30 : 351–367. [Google Scholar]
  8. Weissenbacher MC, Cura E, Segura EL, Hortal M, Baek LJ, Chu YK, Lee HW, 1996. Serological evidence of human hantavirus infection in Argentina, Bolivia and Uruguay. Medicina (B Aires) 56 : 17–22. [Google Scholar]
  9. Schmaljohn C, Hjelle B, 1997. Hantaviruses: a global disease problem. Emerg Infect Dis 3 : 95–104. [Google Scholar]
  10. Mori M, Rothman AL, Kurane I, Montoya JM, Nolte KB, Norman JE, Waite DC, Koster FT, Ennis FA, 1999. High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis 179 : 295–302. [Google Scholar]
  11. Padula PJ, Colavecchia SB, Martinez VP, Della-Valle MOG, Edelstein A, Miguel SDL, Russi J, Riquelme JM, Colucci N, Almiron M, Rabinovich RD, 2000. Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America. J Clin Microbiol 38 : 3029–3035. [Google Scholar]
  12. Verity R, Prasad E, Grimsrud K, Artsob H, Drebot M, Mied-zinski L, Preiksaitis J, 2000. Hantavirus pulmonary syndrome in northern Alberta, Canada: Clinical and laboratory findings for 19 cases. Clin Infect Dis 31 : 942–946. [Google Scholar]
  13. Bohlman MC, Morzunov SP, Meissner J, Taylor MB, Ishibashi K, Rowe J, Levis S, Enria D, Jeor SCS, 2000. Analysis of hantavirus genetic diversity in Argentina: S segment-derived phylogeny. J Virol 76 : 3765–3773. [Google Scholar]
  14. Delfraro A, Clara M, Tomé L, Achaval F, Levis S, Calderón G, Enria D, Lozano M, Russi J, Arbiza J, 2003. Yellow pygmy rice rat (Oligoryzomys flavescens) and hantavirus pulmonary syndrome in Uruguay. Emerg Infect Dis 9 : 846–852. [Google Scholar]
  15. Pini N, Levis S, Calderón G, Ramirez J, Bravo D, Lozano E, Ripoll C, Jeor SS, Ksiazek TG, Barquez RM, Enria D, 2003. Hantavirus infection in humans and rodents, northwestern Argentina. Emerg Infect Dis 9 : 1070–1076. [Google Scholar]
  16. Seijo A, Pini N, Levis S, Coto S, Deodato B, Cernigo B, Bassadoni D, Enria D, 2003. Estudio de hantavirus Seoul en una poblacion humana y roedores en un asentamiento precario de la ciudade de Buenos Aires. Medicina (B Aires) 63 : 193–196. [Google Scholar]
  17. Murúa R, Navarrete M, Cádiz R, Figueroa R, Padula P, Zaror L, Mansilla R, Gonzalez L, Munoz-Pedreros A, 2003. Síndrome Pulmonar por Hantavirus: situación de los roedores reservorios y la población humana en la Décima Regón, Chile. Rev Med Chil 131 : 169–176. [Google Scholar]
  18. Iversson LB, Travassos da Rosa APA, Rosa MDB, Lomar AV, Sasaki MGM, LeDuc JW, 1994. Infecção humana por hantavírus no Sul e Sudeste do Brasil. Rev Assoc Med Bras 40 : 85–92. [Google Scholar]
  19. Vasconcelos M, Lima V, Iversson L, Rosa M, Travassos da Rosa E, Travassos da Rosa A, Rosa ES, Pereira LE, Nassar E, Katz G, Matida LH, Zaparoli MA, Ferreira JJ, Peters CJ, 1997. Hantavirus pulmonary syndrome in the rural area of Juquitiba, São Paulo, Metropolitan Area, Brasil. Rev Inst Med Trop 39 : 237–238. [Google Scholar]
  20. Johnson AM, Souza LTM, Ferreira IB, Pereira LE, Ksiazek TG, Rollin PE, Peters CJ, Nichol ST, 1999. Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol 59 : 527–535. [Google Scholar]
  21. Hjelle B, Jenison S, Torrez-Martinez N, Herring B, Polito SQ, Pichuantes S, Yamada T, Morris C, Elgh F, Lee HW, Artsob H, Dinello R, 1997. Rapid and specific detection of sin nombre virus antibodies in patients with hantavirus pulmonary syndrome by a strip immunoblot assay suitable for field diagnosis. J Clin Microbiol 35 : 600–608. [Google Scholar]
  22. Padula PJ, Rossi CM, Della Valle MO, Martínez PV, Colavecchia SB, Edelstein A, Miguel SDL, Rabinovich RD, Segura EL, 2000. Development and evaluation of a solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 49 : 149–155. [Google Scholar]
  23. Ahn C, Cho JT, Lee JG, Lim CS, Kim YY, Han JS, Kim S, Lee JS, 2000. Detection of Hantaan and Seoul viruses by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP) in renal syndrome patients with hemorrhagic fever. Clin Nephrol 53 : 79–89. [Google Scholar]
  24. Johnson AM, Bowen MD, Ksiazek TG, Willians RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST, 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238 : 115–127. [Google Scholar]
  25. Figueiredo LTM, Moreli ML, Campos GM, Souza RLM, 2003. Hantaviruses in São Paulo State, Brazil. Emerg Infect Dis 9 : 891–892. [Google Scholar]
  26. Young JC, Hansen GR, Graves TK, Deasy MP, Humphreys JG, Gorham KL, Khan AS, Ksiazek TG, Metzger KB, Peters CJ, 2000. The incubation period of hantavirus pulmonary syndrome. Am J Trop Med Hyg 62 : 714–717. [Google Scholar]
  27. Ferreira MS, Nishioka AS, Santos TL, Santos RP, Santos PS, Rocha A, 2000. Hantavirus pulmonary syndrome: clinical aspects of three new cases. Inst Med Trop Sao Paulo 42 : 41–46. [Google Scholar]
  28. Chapman LE, Ellis BA, Koster FT, Sotir M, Ksiazek TG, Mertz GJ, Rollin PE, Baum KF, Pavia AT, Chritensos JC, Rubin PJ, Jolson HM, Behrman RE, Khan AS, Wilson-Bell LJ, Simpson GL, Hawk J, Holman RC, Peters CJ, Ribavirin Study Group, 2002. Discriminators between hantavirus-infected and-uninfected persons enrolled in a trial of intravenous ribavirin for presumptive hantavirus pulmonary syndrome. Clin Infect Dis 34 : 293–304. [Google Scholar]
  29. Lazaro ME, Resa AJ, Barclay CM, Calanni L, Samengo L, Martinez L, Padula PJ, Pini N, Lasala MB, Elsner B, Enria DA, 2000. Hantavirus pulmonary syndrome in southern Argentina. Medicina (B Aires) 60 : 289–301. [Google Scholar]

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  • Received : 03 Jun 2004
  • Accepted : 12 Aug 2004

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