Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Dengue fever and dengue hemorrhagic fever constitute a substantial health burden on the population in Thailand. In this study, the impact of symptomatic dengue virus infection on the families of patients hospitalized at the Kamphaeng Phet Provincial Hospital with laboratory-confirmed dengue in 2001 was assessed, and the disability-adjusted life years (DALYs) lost for fatal and non-fatal cases of dengue were calculated using population level data for Thailand. When we accounted for the direct cost of hospitalization, indirect costs due to loss of productivity, and the average number of persons infected per family, we observed a financial loss of approximately US$61 per family, which is more than the average monthly income in Thailand. The DALYs were calculated using select results from a family level survey, and resulted in an estimated 427 DALYs/million population in 2001. This figure is of the same order of magnitude as the impact of several diseases currently given priority in southeast Asia, such as the tropical cluster (trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, and onchocerciasis), malaria, meningitis, and hepatitis. These results indicate that dengue prevention, control, and research should be considered equally important as that of diseases currently given priority.


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  1. Okanurak K, Sornmani S, Indaratna K, 1997. The cost of dengue hemorrhagic fever in Thailand. Southeast Asian J Trop Med Public Health 28 : 711–717.
    [Google Scholar]
  2. Rothman AL, Ennis FA, 1999. Immunopathogenisis of dengue hemorrhagic fever. Virology 257 : 1–6.
    [Google Scholar]
  3. Mahoney RT, Maynard JE, 1999. The introduction of new vaccines into developing countries. Vaccine 17 : 646–652.
    [Google Scholar]
  4. The World Bank, 1993. World Development Report, 1993: Investing in Health. New York: Oxford University Press.
  5. Murray CJL, 1994. Quantifying the burden of disease: the technical basis for disability-adjusted life years. Bull World Health Organ 72 : 429–445.
    [Google Scholar]
  6. Murray CJL, Lopez AD, 1996. The Global Burden of Disease: Global Burden of Disease and Injury Series. Volume I. Boston: Harvard School of Public Health, 1996
  7. Murray CJL, Lopez AD, 1996. Global Health Statistics: Global Burden of Disease and Injury Series. Volume II. Boston: Harvard School of Public Health.
  8. Kouri GP, Guzman MG, Bravo JR, Triana C, 1989. Dengue haemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ 67 : 375–380.
    [Google Scholar]
  9. Naing CM, 2000. Assessment of dengue hemorrhagic fever in Myanmar. Southeast Asian J Trop Med Public Health 31 : 636– 641.
    [Google Scholar]
  10. Meltzer MI, Rigau-Perez JG, Clark G, Reiter P, Gubler DJ, 1998. Using disability-adjusted life years to assess the economic impact of dengue in Puerto Rico: 1984–1994. Am J Trop Med Hyg 59 : 265–271.
    [Google Scholar]
  11. Thai Ministry of Public Health, 2001. Epidemiological Report. Bangkok: Thai Ministry of Public Health.
  12. Torres MI, 1997. Impact of an outbreak of dengue fever: a case study from rural Puerto Rico. Human Organ 56 : 19–27.
    [Google Scholar]
  13. World Health Organization, 2001. The World Health Report, 2001: Statistical Annex Table 3. Geneva: World Health Organization.
  14. Okanurak K, Sornmani S, Masngammueng R, Sitaputra P, Krachangsang S, Limsomboon J, 1997. Treatment seeking behavior of DHF patients in Thailand. Southeast Asian J Trop Med Public Health 28 : 351–358.
    [Google Scholar]
  15. Household Socio-Economic Survey, 2000. Bangkok, Thailand: Statistical Forecasting Bureau. National Statistics Office, Economic Statistics Division, Socio-economic Statistics Branch, Household Income Expenditure Section, Table 1 .
  16. Teixeira MD, Barreto ML, Costa MC, Ferreira LD, Vasconcelos PF, Cairncross S, 2002. Dynamics of dengue virus circulation: a silent epidemic in a complex urban area. Trop Med Int Health 9 : 757–762.
    [Google Scholar]
  17. Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 : 480–496.
    [Google Scholar]
  18. Situation of Dengue/Dengue Haemorrhagic Fever in the SouthEast Asia Region, 1998. Geneva: World Health Organization, Regional Office for South-East Asia., http://w3.whosea.org/en/Section10/Section332_1104.htm Accessed October 7, 2004.
  19. Murray CJL, Lopez AD, 1996. The Global Burden of Disease: Global Burden of Disease and Injury Series. Volume I. Boston: Harvard School of Public Health, 206–207.
  20. Shepard DS, Suaya JA, Halstead SB, Nathan MB, Gubler DJ, Mahoney RT, Wang DNC, Meltzer M, 2004. Cost-effectiveness of a pediatric dengue vaccine. Vaccine 22 : 1275–1280.
    [Google Scholar]

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  • Received : 17 Aug 2004
  • Accepted : 18 Nov 2004
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