Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A shift from a T1 to a T2 immune response has been observed during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4–0.47 versus 1.3, 1.0–1.9; = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; = 0.001). These findings suggest that a T2 immune response occurs in patients with dengue around the time of defervescence.


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  • Received : 26 Jul 2004
  • Accepted : 19 Nov 2004

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