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Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

A shift from a T1 to a T2 immune response has been observed during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4–0.47 versus 1.3, 1.0–1.9; = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; = 0.001). These findings suggest that a T2 immune response occurs in patients with dengue around the time of defervescence.

Copyright 2005 The American Society of Tropical Medicine
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References

  1. Kurane I, Innis BL, Nimmannitya S, Nisalak A, Meager A, Ennis FA, 1993. High levels of interferon alpha in the sera of children with dengue virus infection. Am J Trop Med Hyg 48 : 222–229. [Google Scholar]
  2. Braga EL, Moura P, Pinto LM, Ignacio SR, Oliveira MJ, Cordeiro MT, Kubelka CF, 2001. Detection of circulant tumor necrosis factor-alpha, soluble tumor necrosis factor p75 and interferon-gamma in Brazilian patients with dengue fever and dengue hemorrhagic fever. Mem Inst Oswaldo Cruz 96 : 229–232. [Google Scholar]
  3. Nguyen TH, Lei HY, Nguyen TL, Lin YS, Huang KJ, Le BL, Lin CF, Yeh TM, Do QH, Vu TQ, Chen LC, Huang JH, Lam TM, Liu CC, Halstead SB, 2004. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis 189 : 221–232. [Google Scholar]
  4. Gagnon SJ, Mori M, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL, 2002. Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections. J Med Virol 67 : 41–46. [Google Scholar]
  5. Chaturvedi UC, Elbishbishi EA, Agarwal R, Raghupathy R, Nagar R, Tandon R, Pacsa AS, Younis OI, Azizieh F, 1999. Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol 59 : 335–340. [Google Scholar]
  6. World Health Organization, 2003. Dengue fever in India—update. Available at URL:http://www.who.int/csr/don/2003_11_12/en/. Accessed July 24, 2004.
  7. Dar L, Broor S, Sengupta S, Xess I, Seth P, 1999. The first major outbreak of dengue hemorrhagic fever in Delhi, India. Emerg Infect Dis 5 : 589–590. [Google Scholar]
  8. World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization.
  9. Liu CC, Huang KJ, Lin YS, Yeh TM, Liu HS, Lei HY, 2002. Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. J Med Virol 68 : 241–252. [Google Scholar]
  10. Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, Suntayakorn S, Ennis FA, Rothman AL, 1999. Impaired T cell proliferation in acute dengue infection. J Immunol 162 : 5609–5615. [Google Scholar]
  11. Romagnani S, 1995. Biology of human TH1 and TH2 cells. J Clin Immunol 15 : 121–129. [Google Scholar]
  12. Vercelli D, Jabara HH, Lauener RP, Geha RS, 1990. IL-4 inhibits the synthesis of IFN-γ and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol 144 : 570–573. [Google Scholar]
  13. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue haemorrhagic fever. Lancet 352 : 971–977. [Google Scholar]
  14. Koraka P, Murgue B, Deparis X, Setiati TE, Suharti C, van Gorp EC, Hack CE, Osterhaus AD, Groen J, 2003. Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity. J Med Virol 70 : 91–98. [Google Scholar]
  15. King CA, Marshal JS, Alshurafa H, Anderson R, 2000. Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line. J Virol 74 : 7146–7150. [Google Scholar]
  16. King CA, Anderson R, Marshall JS, 2002. Dengue virus selectively induces human mast cell chemokine production. J Virol 76 : 8408–8419. [Google Scholar]
  17. Miguez-Burbano MJ, Jaramillo CA, Palmer CJ, Shor-Posner G, Velasquez LS, Lai H, Baum MK, 1999. Total immunoglobulin E levels and dengue infection on San Andres islands, Colombia. Clin Diagn Lab Immunol 6 : 624–626. [Google Scholar]
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TH2 IMMUNE RESPONSE IN PATIENTS WITH DENGUE DURING DEFERVESCENCE: PRELIMINARY EVIDENCE
The American Journal of Tropical Medicine and Hygiene 72, 783 (2005); https://doi.org/10.4269/ajtmh.2005.72.783
/content/journals/10.4269/ajtmh.2005.72.783
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  • Received : 26 Jul 2004
  • Accepted : 19 Nov 2004

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