1921
Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The cytoadherence-linked asexual gene 9 () of has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomatic children and adults subject to intense malaria exposure in Madang, Papua New Guinea. The CLAG 9 peptides were immunogenic in adults and children. Antibody responses to peptides 4 and 10 were high across all age groups and detectable in a majority of children less than five years of age. While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease.

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2005-06-01
2017-09-19
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  • Received : 26 Jul 2004
  • Accepted : 14 Sep 2004

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