1921
Volume 72, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the merozoite surface protein 1 (MSP1), which was relatively uniform in areas with markedly different levels of malaria transmission. In a small sample of adults with symptomless infection, we could not detect any significant correlation between antibodies against these proteins and asymptomatic infection. Our study provided an additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response.

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2005-06-01
2017-11-22
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  • Received : 17 Aug 2004
  • Accepted : 21 Dec 2004

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