Volume 72, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A 38-year-old man living near Phnom Penh (Cambodia) was admitted to a hospital in Paris in June 2001 for a single episode of a generalized grand mal seizure. This episode was preceded by a 9-month history of headaches. Magnetic resonance imaging (MRI) of the head revealed a rounded lesion immediately ahead of the left central sulcus. The resected lesion was about 20 mm in diameter. Histologic examination revealed an elongated but unsegmented metacestode at the center of the lesion. Polymerase chain reaction (PCR) analysis was inconclusive due to formalin-based histologic processing of the tissue. Morphologic analysis based on the histologic sections revealed that the metacestode was a tetra-acetabulate plerocercoid of the order Cyclophyllidea, with a distinct rostellum and pseudosegmentation of the dorsoventrally flattened hindbody. This is the first report of a tetra-acetabulate plerocercoid from a human host and the first report of any cyclophyllidean plerocercoid from the human brain. After 6 weeks, the patient was asymptomatic, neurologic examination was normal, and the brain MRI showed only surgical cavitation. The patient returned to Cambodia.


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  1. Khalil LF, Jones A, Bray RA, 1994. Keys to the Cestode Parasites of Vertebrates. Wallingford: CAB International.
  2. Chervy L, 2002. The terminology of larval cestodes or metacestodes. Syst Parasitol 52 : 1–33.
    [Google Scholar]
  3. Santamaria-Fries M, Fajardo LF, Sogin ML, Olson PD, Relman DA, 1996. Lethal infection by a previously unrecognised metazoan parasite. Lancet 347 : 1797–1801.
    [Google Scholar]
  4. Olson PD, Yoder K, Fajardo L-GL, Marty AM, van de PS, Olivier C, Relman DA, 2003. Lethal invasive cestodiasis in immunosuppressed patients. J Infect Dis 187 : 1962–1966.
    [Google Scholar]
  5. Gutierrez Y, 2000. Diagnostic Pathology of Parasitic Infections with Clinical Correlations. New York, Oxford: Oxford University Press.
  6. Beaver PC, Rolon FA, 1981. Proliferating larval cestode in a man in Paraguay. A case report and review. Am J Trop Med Hyg 30 : 625–637.
    [Google Scholar]
  7. Olson PD, Littlewood DT, Bray RA, Mariaux J, 2001. Interrelationships and evolution of the tapeworms (Platyhelminthes: Cestoda). Mol Phylogenet Evol 19 : 443–467.
    [Google Scholar]
  8. Mariaux J, Olson PD, 2001. Cestode systematics in the molecular era. Littlewood DT, Bray RA, eds. Interrelationships of the Platyhelminths. London: Taylor & Francis, 127–134.
  9. Andersen KA, 1983. Description of the musculature differences in spargana of Spirometra (Cestoda; Pseudophylllidea) and tetrathyridia of Mesocestoides (Cestoda; Cyclophyllidea) and their value in identification. J Helminthol 57 : 334.
    [Google Scholar]
  10. Wardle RA, McLeod JA, 1952. The Zoology of Tapeworms. Minneapolis: The University of Minnesota Press.
  11. Rausch RL, 1994. Family Mesocestoididae Fuhrmann, 1907. Khalil LF, Jones A, Bray RA, eds. Keys to the Cestodes Parasites of Vertebrates. Wallingford, UK: CAB International, 309–314.
  12. Fuentes MV, Galan-Puchades MT, Malone JB, 2003. Short report: a new case report of human Mesocestoides infection in the United States. Am J Trop Med Hyg 68 : 566–567.
    [Google Scholar]
  13. Fincham JE, Seier JV, Verster A, Rose AG, Taljaard JJ, Woodroof CW, Rutherfoord GS, 1995. Pleural Mesocestoides and cardiac shock in an obese vervet monkey (Cercopithecus aethiops). Vet Pathol 32 : 330–333.
    [Google Scholar]
  14. Hubbard GB, Gardiner CH, Bellini S, Ehler WJ, Conn DB, King MM, 1993. Mesocestoides infection in captive olive baboons (Papio cynocephalus anubis). Lab Anim Sci 43 : 625–627.
    [Google Scholar]
  15. Reid WA, Reardon MJ, 1976. Mesocestoides in the baboon and its development in laboratory animals. J Med Primatol 5 : 345–352.
    [Google Scholar]
  16. Marty AM, Neafie RC, 2000. Hymenolepiasis and miscellaneous cyclophyllidiases. Meyers WM, ed. Pathology of Infectious Diseases. Washington: Armed Forces Institute of Pathology, American Registry of Pathology, 197–214.
  17. Georgiev BB, Kornyushin VV, 1994. Family Paruterinidae Fuhrmann, 1907 (sensu lato). Khalil LF, Jones A, Bray RA., eds. Keys to the Cestodes Parasites of Vertebrates. Wallingford, UK: CAB International, 559–584.

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  • Received : 20 May 2004
  • Accepted : 13 Sep 2004
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