1921
Volume 72, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Thai patients with scrub typhus caused by the intracellular pathogen displayed elevated plasma concentrations of granzymes A and B, interferon-γ (IFN)-γ–inducible protein 10, and monokine induced by IFN-γ. These data suggest that activation of cytotoxic lymphocytes is part of the early host response to scrub typhus.

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References

  1. Seong SY, Choi MS, Kim IS, 2001. Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect 3 : 11–21. [Google Scholar]
  2. Silpapojakul K, Chupuppakarn S, Yuthasompob S, Varachit B, Chaipak D, Borkerd T, 1991. Scrub and murine typhus in children with obscure fever in the tropics. Pediatr Infect Dis J 10 : 200–203. [Google Scholar]
  3. Raupach B, Kaufmann SH, 2001. Immune responses to intracellular bacteria. Curr Opin Immunol 13 : 417–428. [Google Scholar]
  4. Chierakul W, de Fost M, Suputtamongkol Y, Limpaiboon R, Dondorp A, White NJ, van der Poll T, 2004. Differential expression of interferon (IFN)-γ and IFN-γ-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clin Immunol 113 : 140–144. [Google Scholar]
  5. Russell JH, Ley TJ, 2002. Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 20 : 323–370. [Google Scholar]
  6. Farber JM, 1997. Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 61 : 246–257. [Google Scholar]
  7. Brown GW, Shirai A, Rogers C, Groves MG, 1983. Diagnostic criteria for scrub typhus: probability values for immunofluorescent antibody and Proteus OXK agglutinin titers. Am J Trop Med Hyg 32 : 1101–1107. [Google Scholar]
  8. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B, 1996. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 184 : 963–969. [Google Scholar]
  9. Spaeny-Dekking EH, Hanna WL, Wolbink AM, Wever PC, Kummer AJ, Swaak AJ, Middeldorp JM, Huisman HG, Froelich CJ, Hack CE, 1998. Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol 160 : 3610–3616. [Google Scholar]
  10. Wever PC, Spaeny LH, van der Vliet HJ, Rentenaar RJ, Wolbink AM, Surachno J, Wertheim PM, Schellekens PT, Hack CE, ten Berge IJ, 1999. Expression of granzyme B during primary cytomegalovirus infection after renal transplantation. J Infect Dis 179 : 693–696. [Google Scholar]
  11. Lauw FN, Simpson AJ, Hack CE, Prins JM, Wolbink AM, van Deventer SJ, Chaowagul W, White NJ, van der Poll T, 2000. Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. J Infect Dis 182 : 206–213. [Google Scholar]
  12. Lauw FN, Simpson AJ, Prins JM, Smith MD, Kurimoto M, van Deventer SJ, Speelman P, Chaowagul W, White NJ, van der Poll T, 1999. Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. J Infect Dis 180 : 1878–1885. [Google Scholar]
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  • Received : 26 Aug 2004
  • Accepted : 03 Oct 2004

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