1921
Volume 72, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Two hundred twenty-six consecutive adult patients with cutaneous leishmaniasis in Colombia were treated with Glucantime and 81% were cured. The 19% who failed treatment had received a statistically significant lower total amount of antimony (354 mg/kg) than those who were cured (405 mg/kg) ( = 0.002). Thirty-nine of the failures were re-treated with Glucantime and 59% were cured. This large experience on initial and re-treatment cure rates probably represents the values found in clinical practice. In this series, parasite resistance may have been induced by the relatively low initial dose of antimony administered to some patients.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2005.72.421
2005-04-01
2017-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/72/4/0720421.html?itemId=/content/journals/10.4269/ajtmh.2005.72.421&mimeType=html&fmt=ahah

References

  1. Velez I, Agudelo S, Hendrickx E, Puerta J, Grogl M, Modabber F, Berman J, 1997. Inefficacy of allopurinol for Colombian cutaneous leishmaniasis: a randomized, controlled trial. Ann Intern Med 126 : 232–236.
  2. Soto J, Fuya P, Herrera R, Berman J, 1998. Topical paromomycin/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment for American cutaneous leishmaniasis: controlled study. Clin Infect Dis 26 : 56–58.
  3. Navin TR, Arana BA, Arana FE, de Merida AM, Castillo AL, Pozuelos JL, 1990. Placebo-controlled clinical trial of meglumine antimonate (glucantime) vs. localized controlled heat in the treatment of cutaneous leishmaniasis in Guatemala. Am J Trop Med Hyg 42 : 43–50.
  4. Navin TR, Arana BA, Arana FE, Berman JD, Chajon JF, 1992. Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala. J Infect Dis 165 : 528–534.
  5. Romero GA, Guerra MV, Paes MG, Macedo VO, 2001. Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate. Am J Trop Med Hyg 65 : 456–465.
  6. Palacios R, Osorio LE, Grajalew LF, Ochoa MT, 2001. Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species. Am J Trop Med Hyg 64 : 187–193.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2005.72.421
Loading
/content/journals/10.4269/ajtmh.2005.72.421
Loading

Data & Media loading...

  • Received : 04 Feb 2004
  • Accepted : 05 May 2004

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error