1921
Volume 72, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The gold standard serodiagnostic assay for cysticercosis and neurocysticercosis, diseases caused by the metacestode of , uses lentil lectin-purified glycoprotein (LLGP) in a Western blot assay. We tested two antigens derived from LLGP, synthetic TS18var1 (sTS18var1) and recombinant GP50 antigen (rGP50), in an enzyme-linked immunosorbent assay (ELISA) using serum and cerebrospinal fluid (CSF) samples. The sensitivity for serum and CSF was 94.7% and 100% for rGP50 and 90.4% and 90.2% for sTS18var1, respectively. The specificity for serum and CSF samples was 93.8% and 100% for rGP50 and 90.3% and 98.0% for sTS18var1, respectively. The use of these antigens individually or combined as a diagnostic antigen cocktail eliminates the need for purification of antigens from parasite material and offers the advantage of using a simple and quantitative ELISA format.

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2005-03-01
2017-11-22
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  • Received : 09 Jul 2004
  • Accepted : 09 Oct 2004

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