1921
Volume 72, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The aim of the study was to assess whether infections with isolates encoding the chloroquine resistance transporter () gene K76T polymorphism, a molecular marker for chloroquine resistance, are associated with multiple infections, age, or clinical signs of malaria in a semi-immune population in a holoendemic area of Burkina Faso. The parameters of interest were investigated in 210 -positive inhabitants. Logistic regression analysis showed that K76T-carrying isolates are significantly more likely to cause anemia and splenomegaly. Furthermore, we found that infections with isolates encoding K76T are dependent on age rather than multiple infections. Our findings suggest that K76T might serve as a valuable marker for assessing the long-term clinical effect of chronic infections with chloroquine-resistant isolates in populations, without the need of drug efficacy trials.

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2005-03-01
2017-11-18
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  • Received : 06 Feb 2004
  • Accepted : 02 Nov 2004

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