1921
Volume 72, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

To better understand the clinical characteristics of concurrent bacteremia (dual infection) in patients with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and identify predictive risk factors for dual infection, 100 patients with DHF/DSS (7 with a dual infection and 93 with DHF/DSS alone [controls]) were enrolled in this study. A patient with DHF/DSS who lacked three or more of the five most frequently observed manifestations other than fever in controls or showed disturbed consciousness was defined as one with unusual dengue manifestations. Patients with a dual infection were older, and tended to have prolonged fever, higher frequencies of acute renal failure, gastrointestinal bleeding, altered consciousness, unusual dengue manifestations, and DSS. Acute renal failure (odds ratio [OR] = 51.45, = 0.002), and prolonged fever (> 5 days) (OR = 26.07, = 0.017) were independent risk factors for dual infection. Clinicians should be alert to the potential for concurrent bacteremia when treating patients with DHF/DSS who are at risk for dual infection and manage them accordingly.

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2005-02-01
2017-09-26
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References

  1. Gibbons RV, Vaughn DW, 2002. Dengue: an escalating problem. BMJ 324 : 1563–1566.
  2. Gubler DJ, 1997. Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem. Gubler DJ, Kuno G eds. Dengue and Dengue Hemorrhagic Fever. Wallingford, United Kingdom: CAB International, 1–22.
  3. Gubler DJ, Clark GG, 1995. Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis 1 : 55–57.
  4. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue hemorrhagic fever. Lancet 352 : 971–977.
  5. da Fonseca BA, Fonseca SN, 2002. Dengue virus infections. Curr Opin Pediatr 14 : 67–71.
  6. Gregson A, Edelman R, 2003. Dengue virus infection. Pediatr Infect Dis J 22 : 179–181.
  7. Wu YC, Lien JC, Chen HY, 1993. Recent outbreak of dengue in Taiwan. Trop Med 35 : 201–207.
  8. Liu JW, Khor BS, Lee CH, Lee IK, Chen RF, Yang KD, 2003. Dengue hemorrhagic fever in Taiwan. Dengue Bull 27 : 19–23.
  9. Liu HW, Ho TL, Hwang CS, Liao YH, 1989. Clinical observations of virologically confirmed dengue fever in the 1987 outbreak in southern Taiwan. Kaohsiung J Med Sci 5 : 42–49.
  10. Shu PY, Chen LK, Chang SF, Yuen YY, Chow L, Chien LJ, Chin C, Yang HH, Lin TH, Huang JH, 2002. Potential application of nonstructural protein NS1 serotype-specific immunoglobulin G enzyme-linked immunosorbent assay in the seroepidemiologic study of dengue virus infection: correlation of results with those of the plaque reduction neutralization test. J Clin Microbiol 40 : 1840–1844.
  11. Chen RF, Yeh WT, Yang MY, Yang KD, 2001. A model of the real-time correlation of viral titers with immune reactions in antibody-dependent enhancement of dengue-2 infections. FEMS Immunol Med Microbiol 30 : 1–7.
  12. WHO, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. Geneva: World Health Organization.
  13. Pancharoen C, Thisyakorn U, 1998. Coinfections in dengue patients. Pediatr Infect Dis J 17 : 81–82.
  14. Sudjana P, Jusuf H, 1998. Concurrent dengue hemorrhagic fever and typhoid fever infection in adult: case report. Southeast Asian J Trop Med Public Health 29 : 370–372.
  15. Kaur H, John M, 2002. Mixed infection due to Leptospira and dengue. Indian J Gastroenterol 21 : 206.
  16. Charrel RN, Abboud M, Durand JP, Brouqui P, de Lamballerie X, 2003. Dual infection by dengue virus and Shigella sonnei in patient returning from India. Emerg Infect Dis 9 : 271.
  17. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6 : 118–124.
  18. Garcia-Rivera EJ, Rigau-Perez JG, 2003. Dengue severity in the elderly in Puerto Rico. Pan Am J Public Health 13 : 362–368.
  19. Resnick NM, 2001. Geriatric medicine. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds. Harrison’s Principles of Internal Medicine. 15th edition. New York: McGraw-Hill, 36–46.
  20. Mbawuike IN, Acuna CL, Walz KC, Atmar RL, Greenberg SB, Couch RB, 1997. Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12. Mech Ageing Dev 94 : 25–39.
  21. Pancharoen C, Thisyakorn U, 2001. Neurological manifestations in dengue patients. Southeast Asian J Trop Med Public Health 32 : 341–345.
  22. Nogueira RMR, Filippis AMB, Coelho JMO, Sequeira PC, Schatzmayr HG, Paiva FG, Ramos AMO, Miagostovich MP, 2002. Dengue virus infection of the central nervous system (CNS): a case report from Brazil. Southeast Asian J Trop Med Public Health 33 : 68–71.
  23. Yamamoto Y, Takasaki T, Yamada K, Kimura M, Washizaki K, Yoshikawa K, Hitani A, Nakamura T, Iwamoto A, 2002. Acute disseminated encephalomyelitis following dengue fever. J Infect Chemother 8 : 175–177.
  24. Lum LC, Lam SK, Choy YS, George R, Harun F, 1996. Dengue encephalitis: a true entity? Am J Trop Med Hyg 54 : 256–259.
  25. Gubler DJ, Suharyono W, Tan R, Abidin M, Sie A, 1981. Viraemia in patients with naturally acquired dengue infection. Bull World Health Organ 59 : 623–630.
  26. George R, Liam CK, Chua CT, Lam SK, Pang T, Geethan R, Foo LS, 1988. Unusual clinical manifestations of dengue virus infection. Southeast Asian J Trop Med Public Health 19 : 585–590.
  27. Hommel D, Talarmin A, Reynes JM, Hulin A, 1999. Acute renal failure associated with dengue fever in French Guiana. Nephron 83 : 183.
  28. Gunasekera HH, Adikaram AV, Herath CA, Samarasinghe HH, 2000. Myoglobinuric acute renal failure following dengue viral infection. Ceylon Med J 45 : 181.
  29. Davis JS, Bourke P, 2004. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 38e : 109–111.
  30. Tanphaichitr VS, Chonlasin R, Suwantol L, Pung-Amritt P, Tachavanich K, Yogsan S, Viprakasit V, 2002. Effect of red blood cell glucose-6-phosphate dehydrogenase deficiency on patients with dengue hemorrhagic fever. J Med Assoc Thai 85 (suppl 2): S522–S529.
  31. Chen WP, Chen SJ, Wei JC, Hwang BT, 1987. Screening for glucose-6-phosphate (G-6-PD) deficiency in the Chinese newborns and the correlation between infants with G-6-PD deficiency and their parents’ nativities. Zhonghua Yi Xue Za Zhi (Taipei) 40 : 443–450.
  32. Suharti C, van Gorp EC, Setiati TE, Dolmans WM, Djokomoeljanto RJ, Hack CE, ten CH, van der Meer JW, 2002. The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome. Thromb Haemost 87 : 42–46.
  33. Lin CF, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Chiu SC, Lin YS, 2002. Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol 169 : 657–664.
  34. Courageot MP, Catteau A, Despres P, 2003. Mechanisms of dengue virus-induced cell death. Adv Virus Res 60 : 157–186.
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  • Received : 17 Jul 2004
  • Accepted : 30 Aug 2004

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