1921
Volume 72, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Experimental infection of marmoset monkeys () with serovar Copenhageni showed microscopic patterns of tissue reactions comparable to those seen in the severe forms of human leptospirosis, including intra-alveolar hemorrhage. The most impressive microscopic changes were seen in the lung and kidney of animals killed at days 6 and 12 after inoculation. There were extensive and irregular areas of hemorrhage predominating around main bronchial branches or diffusely spread to the pulmonary parenchyma, as well as severe tubulointerstitial nephritis. Antibody response detected by the microscopic agglutination test was quantitatively similar to those seen in humans and paralleled severity of tissue lesions. The distribution of leptospires or antigenic debris in infected tissues was observed by immunofluorescence and confocal laser scanning microscopy. Large numbers of typical leptospires were seen in the lumen of proximal renal tubules. Positive reactions showing antigenic debris were closely associated with sites of tissue damage.

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2005-01-01
2017-11-17
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References

  1. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM, 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3 : 757–771.
  2. Covic A, Goldsmith DJ, Gusbeth-Tatomir P, Seica A, Covic M, 2003. A retrospective 5-year study in Moldova of acute renal failure due to leptospirosis: 58 cases and a review of the literature. Nephrol Dial Transplant 18 : 1128–1134.
  3. Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW, 1999. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 354 : 820–825.
  4. Kobayashi Y, 2001. Clinical observation and treatment of leptospirosis. J Infect Chemother 7 : 59–68.
  5. Pereira da Silva JJ, Dalston MO, de Carvalho JEM, Setúbal S, de Oliveira JMC, Pereira MM, 2002. Clinicopathological and immunhistochemical features of the severe pulmonary form of leptospirosis. Rev Soc Bras Med Trop 35 395–399.
  6. Gonçalves AJR, de Carvalho JE, Guedes e Silva JB, Rozembaum R, Vieira AR, 1992. Hemoptysis and the adult respiratory distress syndrome as the cause of death in leptospirosis. Changes in the clinical and anatomicopathological patterns. Rev Soc Bras Med Trop 25 : 261–270.
  7. O’Neil KM, Rickman LS, Lazarus AA, 1991. Pulmonary manifestations of leptospirosis. Rev Infect Dis 13 : 705–709.
  8. Marotto PC, Nascimento CM, Eluf-Neto J, Maroto MS, Andrade L, Sztanjbok J, Seguro AC, 1999. Acute lung injury in leptospirosis: clinical and laboratory features outcome, and factors associated with mortality. Clin Infect Dis 29 : 1561–1563.
  9. Pereira da Silva JJ, Dalston MO, de Carvalho JEM, Setúbal S, de Oliveira JMC, Pereira MM, 2002. Clinicopathological and immunohistochemical features of the severe pulmonary form of leptospirosis. Rev Soc Bras Med Trop 35 : 395–399.
  10. Trevejo RT, Rigau-Perez JG, Ashford DA, McClure EM, Jarquin-Gonzalez C, Amador JJ, de los Reyes JO, Gonzalez A, Zaki SR, Shieh WJ, McLean RG, Nasci RS, Weyant RS, Bolin CA, Bragg SL, Perkins BA, Spiegel RA, 1998. Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J Infect Dis 178 : 1457–1463.
  11. Vinetz JM, 2001. Leptospirosis. Curr Opin Infect Dis 14 : 527–538.
  12. Smythe L, Dohnt M, Symonds M, Barnett L, Moore M, Brookes D, Vallanjon M, 2000. Review of leptospirosis notifications in Queensland and Australia: January 1998–June 1999. Commun Dis Intell 24 : 153–157.
  13. Park SK, Lee SH, Rhee YK, Kang SK, Kim KJ, Kim MC, Kim KW, Chang WH, 1989. Leptospirosis in Chonbuk Province of Korea in 1987: a study of 93 patients. Am J Trop Med Hyg 41 : 345–351.
  14. Seijo A, Coto H, San Juan J, Videla J, Deodato B, Cernigoi B, Messina OG, Collia O, Bassadoni D, Schtirbu R, Olenchuck A, Mazzonelli GD, Parma A, 2002. Lethal leptospiral pulmonary hemorrhage: an emerging disease in Buenos Aires, Argentina. Emerg Infect Dis 8 : 1004–1005.
  15. Vijayachari P, Sehgal SC, Goris MG, Terpstra WJ, Hartskeerl RA, 2003. Leptospira interrogans serovar Valbuzzi: a cause of severe pulmonary hemorrhages in the Andamana Islands. J Med Microbiol 52 : 913–918.
  16. Niwattayakul K, Homvijitkul J, Niwattakayakul S, Khow O, Sitprija V, 2002. Hypotension, renal failure and pulmonary complications in leptospirosis. Ren Fail 24 : 297–305.
  17. Pereira MM, Matsuo MG, Bauab AR, Vasconcellos SA, Moraes ZM, Baranton G, Saint Girons I, 2000. A clonal subpopulation of Leptospira interrogans sensu stricto is the major cause of leptospirosis outbreaks in Brazil. J Clin Microbiol 38 : 450–452.
  18. Katz AR, Ansdell VE, Effler PV, Middleton CR, Sasaki DM, 2002. Leptospirosis in Hawaii, 1974–1998: epidemiologic analysis of 353 laboratory-confirmed cases. Am J Trop Med Hyg 66 : 61–70.
  19. Dai B, 1992. Advances in research on Leptospira and human leptospirosis in China. Chin Med Sci J 7 : 239–243.
  20. Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu G, Lu LF, Jian HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ, Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint Girons I, Sommerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP, 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422 : 888–893.
  21. Interagency Primate Steering Committte, 1978. National Primate Plan. Bethesda, MD: U.S. Department of Health Education and Welfare.
  22. Terpstra WJ, Adler B, Ananyina J, André-Fontaine G, Ansdell V, Ashford DA, Bakoss P, Baranton G, Bamea A, Bolin CA, Ciceroni L, Cinco M, Coleman TJ, Collares Pereira M, Edwards C, Ellis WA, Feresu SB, Fujikura T, Gonzales-Salas L, Hartskeerl RA, Korver H, Levett PN, Masusawa T, Muthusethupathi MA, Pereira MM, Perolat P, Saint Girons I, Sasaki DM, Schönberg A, Sehgal SC, Manhua S, Smits HL, Smits SP, Smythe LD, Spiegel RA, Xugao J, Yanagihara Y, Zuerner RL, Braam P, Cosivi O, 2003. Human Leptospirosis: Guidance for Diagnosis, Surveillance and Control: Geneva: World Health Organization and International Leptospirosis Society.
  23. Lennert K, 1978. Malignant Lymphomas other than Hodgkin’s Disease. Berlin: Springer-Verlag.
  24. Stevens AE, Headlam DG, Pritchard CJ, Thoms JA, Morris JA, 1985. Monoclonal antibodies for diagnosis of infection with Leptospira interrogans serovar hardjo by immunofluorescence. Vet Rec 116 : 593–594.
  25. Zaki SR, Shieh WJ, 1996. Leptospirosis associated with outbreak of acute febrile ilness and pulmonary hemorrhage, Nicaragua, 1995. The Epidemic Working Group at the Ministry of Health in Nicaragua. Lancet 347 : 535–536.
  26. Brown PD, Carrington DG, Gravekamp C, van de Kemp H, Edwards CN, Jones SR, Prussia PR, Garriques S, Terpstra WJ, Levett PN, 2003. Direct detection of leptospiral material in human postmortem samples. Res Microbiol 154 : 581–586.
  27. Nally JE, Chantranuwat C, Wu XY, Fishbein MC, Pereira MM, Pereira de Silva JJ, Blanco DR, Lovett MA, 2004. Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis. Am J Pathology 164 : 1115–1127.
  28. Guedes e Silva JB, Paiva LM, Pereira da Silva JJ, de Souza Netto BA, 1980. Pathological involvement of human gastrocnemius muscle in leptospirosis (a study in 63 patients). Rev Bras Pesq Med Biol 13 : 9–13.
  29. Pereira da Silva JJ, Netto BA, Lilembaum W, Alvim ME, de Oliveira AV, 1995. The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs. Rev Soc Bras Med Trop 28 : 169–177.
  30. Pereira MM, Andrade J, Lacerda NM, Batoréu RS, Marchevsky RS, Ribeiro dos Santos R, 1997. Demonstration of leptospiral antigens on tissues using monoclonal antibodies and avidinbiotin peroxidase staining. Exp Toxicol Pathol 49 : 505–511.
  31. Hambleton P, Baskerville A, Marshall RB, P.W. H-S, Adams GD, 1980. Metabolic sequelae of experimental leptospirosis in grivet monkeys. Br J Exp Pathol 61 : 16–21.
  32. Marshall RB, Baskerville A, Hambleton P, Adams GD, 1980. Benign leptospirosis: the pathology of experimental infection of monkeys with Leptospira interrogans servars balcanica and tarassovi. Br J Exp Pathol 61 : 124–131.
  33. Palmer MF, Waitkins SA, Fitzgeorge RB, Baskerville A, 1987. Experimental infection of monkeys with Leptospira interrogans serovar hardjo. Epidemiol Infect 98 : 191–197.
  34. Hermann AC, Herron AJ, Hines ME, Orchar EA, Altman NH, 1993. Leptospirosis in a white-lipped tamarin (Saguinus labiatus). Lab Anim Sci 43 : 258–259.
  35. Perolat P, Poingt JP, Vie JC, Jouaneau C, Baranton G, Gysin J, 1992. Occurrence of severe leptospirosis in a breeding colony of squirrel monkeys. Am J Trop Med Hyg 46 : 538–545.
  36. Noguchi H, Muller HR, Torres O, Silva F, Martins MD, Vianna G, Bião M, 1924. Experimental studies of yellow fever in northern Brazil. Monogr Rockefeller Inst Med Res 20 : 1–35.
  37. Ludlage E, Mansfield K, 2003. Clinical care and diseases of the common marmoset (Callithrix jacchus). Comp Med 53 : 369–382.
  38. Neubert R, Foerster M, Nogueira AC, Helge H, 1996. Cross-reactivity of antihuman monoclonal antibodies with cell surface receptors in the common marmoset. Life Sci 58 : 317–324.
  39. Adler B, Faine S, 1977. Host immunological mechanisms in the resistance of mice to leptospiral infections. Infect Immun 17 : 67–72.
  40. Masuzawa T, Hasuiguchi Y, Nakamura R, Suzuki R, Shimizu T, Inamoto Y, Morita T, Yanagihara Y, 1991. Experimental lethal infection of Leptospira interrogans in mice treated with cyclophosphamide. Can J Microbiol 37 : 312–315.
  41. Pereira MM, Andrade J, Marchevsky RS, Ribeiro dos Santos R, 1998. Morphological characterization of lung and kidney lesions in C3H/He mice infected with Leptospira interrogans serovar icterohaemorrhagiae: Defect of CD4+ and CD8+ T-cells are prognosticators of the disease progression. Exp Toxicol Pathol 50 : 191–198.
  42. De Brito T, Böhm GM, Yasuda PH, 1979. Vascular damage in acute experimental leptospirosis of the guinea pig. J Pathol 128 : 177–182.
  43. Nicodemo AC, Duarte MI, Alves VA, Takakura CF, Santos RT, Nicodemo EL, 1997. Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia. Am J Trop Med Hyg 56 : 181–187.
  44. Werts C, Tapping RI, Mathison JC, Chuang TH, Karavchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias SP, Ulevitch RJ, 2001. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2 : 286–288.
  45. Merien F, Truccolo J, Rougier Y, Baranton G, Perolat P, 1998. In vivo apoptosis of hepatocytes in guinea pigs infected with Leptospira interrogans serovar icterohaemorrhagiae. FEMS Microbiol Lett 169 : 95–102.
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  • Received : 21 May 2003
  • Accepted : 22 Jan 2004

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