Volume 72, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A multi-test strip dotblot immunoassay for the diagnosis of typhoid fever, scrub typhus, murine typhus, dengue virus infection and leptospirosis was evaluated in Thai adults presenting to hospital with acute, undifferentiated fever. The kit gave multiple positive test results in 33 of 36 patients with defined infections and was therefore not a useful admission diagnostic tool.


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  1. Farooqui BJ, Khurshid M, Ashfaq MK, Khan MA, 1991. Comparative yield of Salmonella typhi from blood and bone marrow cultures in patients with fever of unknown origin. J Clin Pathol 44 : 258–259.
  2. Brown GW, Shirai A, Jegathesan M, Burke DS, Twartz JC, Saunders JP, Huxsoll DL, 1984. Febrile illness in Malaysia: an analysis of 1,629 hospitalized patients. Am J Trop Med Hyg 33 : 311–315.
  3. Update, 1998. leptospirosis and unexplained acute febrile illness among athletes participating in triathlons-Illinois and Wisconsin, 1998. MMWR Morb Mortal Wkly Rep 47 : 673–676.
  4. Watt G, Parola P, 2003. Scrub typhus and tropical rickettsioses. Curr Opin Infect Dis 16 : 429–456.
  5. Watt G, Jongsakul K, Chouriyagune C, Paris R, 2003. Differentiating dengue virus infection from scrub typhus in Thai adults with fever. Am J Trop Med Hyg 68 : 536–538.
  6. Watt G, Jongsakul K, Suttinont C, 2003. Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. Am J Trop Med Hyg 68 : 89–91.
  7. Effler PV, Bogard AK, Domen HY, Katz AR, Higa HY, Sasaki DM, 2002. Evaluation of eight rapid screening tests for acute leptospirosis in Hawaii. J Clin Microbiol 40 : 1464–1469.
  8. Watt G, Strickman D, Kantipong P, Jongsakul K, Paxton H, 1998. Performance of a dot blot immunoassay for the rapid diagnosis of scrub typhus in a longitudinal case series. J Infect Dis 177 : 800–802.
  9. Watanaverradej V, Endy TP, Samakoses R, Kerdpanich A, Simasathien S, Polprasert N, Aree C, Vaughn DW, Ho C, Nisalak A, 2003. Transplacentally transferred maternal-infant antibodies to dengue virus. Am J Trop Med Hyg 69 : 123–128.
  10. Tay ST, Rohani MY, 2002. The use of the indirect immunoperoxidase test for the serodiagnosis of rickettsial diseases in Malaysia. Southeast Asian J Trop Med Public Health 33 : 312– 313.
  11. Winslow WE, Merry DJ, Pirc ML, Devine PL, 1997. Evaluation of a commercial enzyme-linked immunosorbent assay detection of immunoglobulin M antibody in diagnosis of human leptospiral infection. J Clin Microbiol 35 : 1938–1942.
  12. Nimmannitya S, 1987. Clinical spectrum and management of dengue haemorrhagic fever. Southeast Asian J Trop Med Public Health 18 : 392–397.

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  • Received : 15 Jun 2004
  • Accepted : 23 Jul 2004

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