Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


It is known that peritoneal murine macrophages activated with interferon-γ exert a fungicidal effect against conidia by a nitric oxide (NO)-mediated mechanism. This NO-mediated effect can also be induced by other cytokines such as tumor necrosis factor-α (TNF-α). The aim of this study was to determine if TNF-α-activated peritoneal murine macrophages infected with were able to show fungistatic/fungicidal effects mediated by NO. The results indicated that although macrophage activation with TNF-α did not result in NO production, these cells played an important role in inhibiting the conidia from becoming yeast cells. , the NO-independent inhibitory effect would prove of importance for the establishment of in host tissues.


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  • Received : 13 May 2004
  • Accepted : 14 Jul 2004

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