1921
Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Since and are known to be present in similar environments, there have been many epidemiologic investigations regarding the prevalences of these two organisms. However, cross-reactivity can occur in paracoccidioidin and histoplasmin skin tests, and this usually results in the overestimation of the prevalence of .The prevalence of infection with was evaluated in a cross-sectional study of 298 asymptomatic school children in the Brazilian Amazon region (Mato Grosso State). In this investigation, the reactivity of children to two different antigen preparations, paracoccidioidin and a purified 43-kD glycoprotein (gp43), was compared with or without the co-administration of histoplasmin. In the group of individuals receiving paracoccidioidin who had a positive histoplasmin skin test result, the prevalence of exposure to was 44% (16 of 36). This reactivity to was significantly higher than that observed in other groups, which ranged from 4% to 6% ( < 5 × 10 for each). Overall prevalence was 4.6% (95% confidence interval = 2.5–7.7%). These data suggest that gp43 provides a better estimate of exposure to when the co-administration of histoplasmin is desired.

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  • Received : 03 Oct 2002
  • Accepted : 17 Oct 2003

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