Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with , we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals.


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  1. Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G, 1986. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg 35 : 793–802.
    [Google Scholar]
  2. Buchanan RD, Fine DP, Colley DG, 1973. Schistosoma mansoni: infection in mice depleted of thymus-dependent lymphocytes. II. Pathology: Altered pathogenesis. Am J Pathol 71 : 208–218.
    [Google Scholar]
  3. Lucas S, Musallam R, Bain J, Hassounah O, Bickle Q, Doenhoff M, 1980. The pathological effects of immunosuppression of Schistosoma mansoni-infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with antithymocyte serum, and treatment with hydrocortisone acetate. Trans R Soc Trop Med Hyg 74 : 633–643.
    [Google Scholar]
  4. Karanja DMS, Colley DG, Nahlen BL, Ouma JH, Secor WE, 1997. Studies on schistosomiasis in western Kenya. I. Evidence for immune-facilitated excretion of schistosome eggs from patients with Schistosoma mansoni and human immunodeficiency virus co-infections. Am J Trop Med Hyg 56 : 515–521.
    [Google Scholar]
  5. Richter J, Hatz C, Campagne G, Bergquist NR, Jenkins JM, 2000. Ultrasound in Schistosomiasis: A Practical Guide to the Standardized Use of Ultrasonography for the Assessment of Schistosomiasis-Related Morbidity. Geneva: World Health Organization. (http://www.who.int/tdr/publications/publications/pdf/ultrasound.pdf).
  6. Colley DG, Katz N, Rocha RS, Abrantes W, da Silva AL, Gazzinelli G, 1983. Immune responses during human schistosomiasis mansoni. IX. T-lymphocyte subset analysis by mono-clonal antibodies in hepatosplenic disease. Scand J Immunol 17 : 297–302.
    [Google Scholar]

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  • Received : 14 May 2004
  • Accepted : 01 Jul 2004
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