1921
Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A study was performed to determine the efficacy of praziquantel (PZQ) against . Children (n = 592) infected with received either a single treatment with PZQ (40 mg/kg) or two or three treatments with PZQ at three-week intervals after the initial treatment and efficacy was monitored for nine weeks. Cure rates at three-weeks post-treatment were low (< 50%), suggesting either that worms are killed very slowly or, more likely, that eggs continue to be released from tissues after worm death. Interestingly, a single dose of PZQ showed high efficacy (cure rate > 83% and egg reduction rate > 98%) when assessed from six weeks post-treatment onward. There were no significant differences in cure rates or intensity of infection between the three cohorts at any point in the study, despite the different treatment regimens. Since children were in contact with transmission sites during the study period, the results suggest good efficacy of PZQ against all stages of , including the immature worms.

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2004-12-01
2017-11-24
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References

  1. WHO, 1993. The Control of Schistosomiasis: Second Report of the WHO Expert Committee. Geneva: World Health Organization.
  2. Hagan P, Appleton CC, Coles GC, Kusel JR, Tchuem Tchuenté LA, 2004. Schistosomiasis control: keep taking the tablets. Trends Parasitol 20 : 92–97.
  3. Gönnert R, Andrews P, 1977. Praziquantel, a new broad spectrum antischistosomal agent. Z Parasitenkund 52 : 129–150.
  4. Sabah AA, Fletcher C, Webbe G, Doenhoff MJ, 1986. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 61 : 294–303.
  5. Gryseels B, Stelma FF, Talla I, van Dam GJ, Polman K, Sow S, Diaw M, Sturrock RF, Doehring-Schwerdtfeger E, Kardorff R, Decam C, Niang M, Deelder AM, 1994. Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal. Trop Geogr Med 46 : 209–219.
  6. Stelma FF, Sall S, Daff B, Sow S, Niang M, Gryseels B, 1997. Oxamniquine cures Schistosoma mansoni infection in a focus in which cure rates with praziquantel are unusually low. J Infect Dis 176 : 304–307.
  7. Picquet M, Vercruysse J, Shaw DJ, Diop M, Ly A, 1998. Efficacy of praziquantel against Schistosoma mansoni in northern Senegal. Trans R Soc Trop Med Hyg 92 : 90–93.
  8. Gryseels B, Mbaye A, De Vlas SJ, Stelma FF, Guissé F, Van Lieshout L, Faye D, Diop M, Ly A, Tchuem Tchuenté LA, Engels D, Polman K, 2001. Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Trop Med Int Health 6 : 864–873.
  9. Tchuem Tchuenté LA, Southgate VR, Mbaye A, Engels D, Gryseels B, 2001. The efficacy of praziquantel against Schistosoma mansoni in Ndombo, northern Senegal. Trans R Soc Trop Med Hyg 95 : 65–66.
  10. WHO, 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis. World Health Organ Tech Rep Ser 912.
  11. Guirguis FR, 2003. Efficacy of praziquantel and Ro 15–5458, a 9-acridanone-hydrazone derivative, against Schistosoma haematobium. Arzneimittelforschung 53 : 57–61.
  12. Loker ES, 1983. A comparative study of the life-histories of mammalian schistosomes. Parasitology 87 : 343–369.
  13. Tchuem Tchuenté LA, Southgate VR, Njiokou F, Njiné T, Kouemeni L, Jourdane J, 1997. The evolution of schistosomiasis at Loum, Cameroon: replacement of Schistosoma intercalatum by S. haematobium through introgressive hybridisation. Trans R Soc Trop Med Hyg 91 : 664–665.
  14. Katz N, Dias EP, Souza CP, Bruce JI, Coles GC, 1989. Rate of action of schistosomicides in mice infected with Schistosoma mansoni. Rev Soc Bras Med Trop 22 : 183–186.
  15. McMahon JE, Kolstrup N, 1979. Praziquantel: a new schistosomicide against S. haematobium. BMJ 2 : 1396–1399.
  16. Giboda M, Loudova J, Shonova O, Bouckova E, Horacek J, Numrich P, Ruppel A, Vitovec J, Lukes S, Noll P, 1992. Efficacy of praziquantel treatment of schistosomiasis in a non-endemic country: a follow-up of parasitological, clinical and immunological parameters. J Hyg Epidemiol Microbiol Immunol 36 : 346–355.
  17. Herwaldt BL, Tao LF, van Pelt W, Tsang VC, Bruce JI, 1995. Persistence of Schistosoma haematobium infection despite multiple courses of therapy with praziquantel. Clin Infect Dis 20 : 309–315.
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  • Received : 23 Apr 2004
  • Accepted : 05 Aug 2004

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