Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Mutations in β-globin, glucose-6-phosphate dehydrogenase, and promoters for tumor necrosis factor-α and inducible nitric oxide synthase (iNOS) were examined for associations with the incidence of symptomatic malaria in a cohort of 307 Ugandan children. After adjustment of incidence rates for age, water source, use of preventative measures, and proximity to mosquito breeding sites, glucose-6-phosphate dehydrogenase A- heterozygous females had a significantly higher incidence of malaria (incidence rate ratio [IRR] = 1.63, = 0.03) and a trend towards higher parasite densities (37,100 versus 26,200 parasites/μL; = 0.18) compared with wild-type children. Male hemizygotes had trends in the same direction. Heterozygotes for sickle hemoglobin had trends toward a lower incidence of malaria and lower parasite density at presentation. Heterozygotes for the iNOS promoter G954C polymorphism, but not other promoter polymorphisms, had a significantly lower incidence of malaria compared with wild-type children (IRR = 0.69, = 0.05). Host polymorphisms appear to impact upon the incidence of uncomplicated malaria in Ugandan children.


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  • Received : 09 Apr 2004
  • Accepted : 09 Jul 2004

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