1921
Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

To study the genetic diversity of re-emerging in the Republic of Korea, nucleotide sequence variations at the merozoite surface protein-3α (PvMSP-3α) locus were analyzed using 24 re-emerging isolates and 4 isolates from imported cases. Compared with the well known Belem strain (Brazil), a large number of amino acid substitutions, deletions, and insertions were found at the locus of the isolates examined. The Korean isolates were divided into two allelic types; type I (15 isolates), similar to the Belem strain, and type II (9), similar to the Chess strain (New Guinea). Isolates from imported cases were classified into three types; type III (1 from Malaysia), similar to type B from western Thailand, type IV (1 each from Indonesia and India), and type V (1 from Pakistan), both being new types. Our results have shown that the MSP-3α locus of re-emerging Korean is dimorphic with two allelic types coexisting in the endemic area.

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2004-12-01
2017-09-24
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  • Received : 09 Mar 2004
  • Accepted : 02 Jul 2004

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