1921
Volume 71, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

To study the risk factors for gametocyte carriage, the presence or absence of gametocytes was determined in 2,125 patients with malaria participating in clinical trials at the Hospital for Tropical Diseases in Bangkok, Thailand. Stepwise logistic regression models were used to determine which variables were significantly related to gametocyte carriage. On admission, 615 patients (29%) had detectable gametocytes (before treatment). After treatment had started, an additional 245 patients (11%) developed patent gametocytemia. The variables retained by multivariate analysis were highest observed temperature (adjusted odds ratio [AOR] per °C increase = 0.82, 95% confidence interval [CI] = 0.71–0.94, = 0.006), asexual parasitemia > 9,200/μL (AOR = 2.8, 95% CI = 1.9–4.2, < 0.0001), erythrocyte counts (AOR = 0.8/million/μL increase, 95% CI = 0.67–0.95, = 0.01), monocyte percentage (AOR = 0.93 per % increase, 95% CI = 0.89–0.96, < 0.0001), lymphocyte percentage (AOR = 0.98 per % increase, 95% CI = 0.97–0.99, = 0.006), albumin (AOR = 0.67 per 10 g/mL increase, 95% CI = 0.5–0.9, = 0.007), and anion gap (AOR = 1.1 per unit increase, 95% CI = 1.02–1.14, = 0.009). The possible significance of these observations is discussed.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2004.71.693
2004-12-01
2017-11-23
Loading full text...

Full text loading...

/deliver/fulltext/14761645/71/6/0700693.html?itemId=/content/journals/10.4269/ajtmh.2004.71.693&mimeType=html&fmt=ahah

References

  1. Manson P, Cook GC, Bell DR, 1996. Manson’s Tropical Diseases. London: W. B. Saunders.
  2. Price R, Nosten F, Simpson JA, Luxemburger C, Phaipun L, ter Kuile F, van Vugt M, Chongsuphajaisiddhi T, White NJ, 1999. Risk factors for gametocyte carriage in uncomplicated falciparum malaria. Am J Trop Med Hyg 60 : 1019–1023.
  3. Nacher M, Singhasivanon P, Silachamroon U, Treeprasertsuk S, Tosukhowong T, Vannaphan S, Gay F, Mazier D, Looareesuwan S, 2002. Decreased hemoglobin concentrations, hyperparasitemia, and severe malaria are associated with increased Plasmodium falciparum gametocyte carriage. J Parasitol 88 : 97–101.
  4. von Seidlein L, Drakeley C, Greenwood B, Walraven G, Targett G, 2001. Risk factors for gametocyte carriage in Gambian children. Am J Trop Med Hyg 65 : 523–527.
  5. Sattabongkot J, Maneechai N, Rosenberg R, 1991. Plasmodium vivax: gametocyte infectivity of naturally infected Thai adults. Parasitology 102 : 27–31.
  6. Boyd MF, Stratman-Thomas WK, Muench H, 1935. The occurence of gametocytes of Plasmodium vivax during the primary attack. Am J Trop Med 16 : 133–138.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2004.71.693
Loading
/content/journals/10.4269/ajtmh.2004.71.693
Loading

Data & Media loading...

  • Received : 29 Oct 2003
  • Accepted : 08 Jan 2004

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error