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Volume 71, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

To determine the age-stratified exposure to hepatitis E virus (HEV) in patients attending a tertiary care hospital in southern India, serum samples from 600 individuals were tested using a commercial HEV IgG enzyme-linked immunosorbent assay. Subjects were composed of blood donors, antenatal women, and pre-operative individuals who were negative for hepatitis B surface antigen and antibody to hepatitis C virus with no evidence of liver disease; 200 each were 1–5 and 6–15 years old and 100 each were 16–40 and ≥ 41 years old. One (0.5%) sample was positive in those 1–5 years old, two (1.0%) in those 6–15 years old, eight (8%) in those 16–40 years old, and 13 (13%) in those ≥ 41 years old. The overall seropositivity rate was 4%. However, there was an age-related increase in exposure to HEV that was statistically significant ( < 0.001), with a higher HEV seropositivity in urban individuals.

Copyright 2004 The American Society of Tropical Medicine
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2004-11-01
2018-04-21

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References

  1. Arankalle VA, Chobe LP, Jha J, Chadha MS, Banerjee K, Favorov MO, Kalinina T, Fields H, 1993. Aetiology of acute sporadic non-A, non-B viral hepatitis in India. J Med Virol 40 : 121–125.
  2. Arankalle VA, Chadha MS, Tsarev SA, Emerson SU, Risbud AR, Banerjee K, Purcell RH, 1994. Seroepidemiology of water-borne hepatitis in India and evidence for a third enterically-transmitted hepatitis agent. Proc Natl Acad Sci U S A 91 : 3428–3432.
  3. Nakai K, Win KM, Oo SS, Arakawa Y, Abe K, 2001. Molecular characteristic-based epidemiology of hepatitis B, C and E viruses and GB virus C/Hepatitis G virus in Myanmar. J Clin Microbiol 39 : 1536–1539.
  4. Ramachandran J, Eapen CE, Kang G, Abraham P, Hubert DD, Kurian G, Hephzibah J, Mukhopadhya A, Chandy GM, 2004. Hepatitis E superinfection produces severe decompensation in patients with chronic liver disease. J Gastroenterol Hepatol 19 : 134–138.
  5. Yarbough PO, 1998. Diagnosis. Zuckerman AJ, Thomas HC, eds. Viral Hepatitis. Second edition. Churchill Livingston, London: 411–416.
  6. Karetnyi YV, Favorov MO, Khudyakova NS, Weiss P, Bar-Shani S, Handsher R, Aboudy Y, Varsano N, Schwartz E, Levin E, Mendelson E, Fields HA, 1995. Serological evidence for hepatitis E virus infection in Israel. J Med Virol 45 : 316–320.
  7. Zanetti R, Dawson GJ, 1994. Hepatitis type E in Italy: a seroepidemiological survey. J Med Virol 42 : 318–320.
  8. Zaaijer HL, Yin MF, Lelie PN, 1992. Seroprevalence of hepatitis E in The Netherlands (letter). Lancet 340 : 681.
  9. Thomas DL, Mahley RW, Badur S, Palaoqlu KE, Quinn TC, 1993. Epidemiology of hepatitis E virus infection in Turkey. Lancet 341 : 1561–1562.
  10. Lavanchy D, Morel B, Freip C, 1994. Seroprevalance of hepatitis E virus in Switzerland. Lancet 344 : 747–748.
  11. Aggarwal R, Shahi H, Naik S, Yachha SK, Naik SR, 1997. Evidence in favour of high infection rate with hepatitis E virus among young children in India. J Hepatol 26 : 1425–1426.
  12. Arankalle VA, Tsarev SA, Chadha MS, Alling DW, Emerson SU, Banerjee K, Purcell RH, 1995. Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992. J Infect Dis 171 : 447–450.
  13. Khuroo MS, 1991. Hepatitis E: the enterically transmitted non-A, non-B hepatitis. Indian J Gastrolenterol 10 : 96–100.
  14. Mohanavalli B, Dhevahi E, Menon T, Malathi S, Thyagarajan SP, 2003. Prevalence of antibodies to hepatitis A and hepatitis E virus in urban school children in Chennai. Indian Pediatr 40 : 328–331.
  15. Mathur P, Arora NK, Panda SK, Kapoor SK, Jailkhani BL, Irshad M, 2001. Sero-epidemiology of hepatitis E virus (HEV) in urban and rural children of north India. Indian Pediatr 38 : 461–475.
  16. Huang FF, Haqshenas G, Guenette DK, Halbur PG, Schommer SK, Pierson FW, Toth TE, Meng XJ, 2002. Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States. J Clin Microbiol 40 : 1326–1332.
  17. Arankalle VA, Chobe LP, Walimbe AM, Yergolkar PN, Jacob GP, 2003. Swine HEV infection in south India and phylogenetic analysis (1985–1999). J Med Virol 69 : 391–396.
  18. Radhakrishnan S, Raghuraman S, Abraham P, Kurian G, Chandy G, Sridharan G, 2000. Prevalence of enterically transmitted hepatitis viruses in patients attending a tertiary-care hospital in south India. Indian J Pathol Microbiol 43 : 433–436.
  19. John R, Abraham P, Kurien G, Chandy G, Sridharan G, 1997. Sporadic hepatitis E in southern India. Trans R Soc Trop Med Hyg 91 : 392.
  20. Murhekar MV, Sehgal SC, Murhekar KM, Padbhidri SP, Chitambar SD, Arankalle VA, 2002. Changing scenario of hepatitis A virus and hepatitis E virus exposure among the primitive tribes of Andaman and Nicobar Islands, India over the 10-year period 1989–99. J Viral Hepat 9 : 315–321.
  21. Ticehurst J, Popkin TJ, Bryan JP, Innis BL, Duncan JF, Ahmed A, Iqbal Malik I, Kapikian AZ, Legters LJ, Purcell RH, 1992. Association of hepatitis E virus with an outbreak of hepatitis in Pakistan: serologic responses and pattern of virus excretion. J Med Virol 36 : 84–92.
  22. Goldsmith R, Yarbough PO, Reyes GR, Fry KE, Gabor KA, Kamel M, Zakaria S, Amer S, Gaffar Y, 1992. Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egytian children. Lancet 339 : 328–331.
  23. Bryan JP, Tsarev SA, Iqbal M, Ticehurst J, Emerson S, Ahmed A, Duncan J, Rafiqui AR, Malik IA, Purcell RH, Legters LJ, 1994. Epidemic hepatitis E in Pakistan: Patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. J Infect Dis 170 : 517–521.
  24. Chadha MS, Walimbe AM, Arankalle VA, 1999. Retrospective serological analysis of hepatitis E patients: a long-term follow-up study. J Viral Hepat 6 : 457–461.
  25. Khuroo MS, Rustgi VK, Dawson GJ, Mushahwar IK, Yattoo GN, Kamili S, Khan BA, 1994. Spectrum of hepatitis E virus infection in India. J Med Virol 43 : 281–286.
  26. Das K, Agarwal A, Andrew R, Frosner GG, Kar P, 2000. Role of hepatitis E and other hepatotropic virus in aetiology of sporadic acute viral hepatitis: a hospital based study from urban Delhi. Eur J Epidemiol 16 : 937–940.
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AGE-WISE EXPOSURE RATES TO HEPATITIS E VIRUS IN A SOUTHERN INDIAN PATIENT POPULATION WITHOUT LIVER DISEASE
The American Journal of Tropical Medicine and Hygiene 71, 675 (2004); https://doi.org/10.4269/ajtmh.2004.71.675
/content/journals/10.4269/ajtmh.2004.71.675
/content/journals/10.4269/ajtmh.2004.71.675
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  • Received : 30 Apr 2004
  • Accepted : 16 Jun 2004

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