Volume 71, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 and 1 . Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from samples. The high sequence identity between human and rodent samples implicated as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.


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  • Received : 05 Aug 2003
  • Accepted : 15 Jul 2004

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