1921
Volume 71, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The objective of this study was to examine nodules from Mexico, Guatemala, and Ecuador collected over a one-year period (2001) to determine the effects of semi-annual ivermectin treatments on macrofilarial populations. Nodules were sectioned, stained with hematoxylin and eosin, and histologic findings were compared between countries and with historical data prior to the introduction of ivermectin into the region. Nodules from Ecuador had 10 times more dead or moribund worms than the historical control (66.6% versus 6.5%); nodules from patients from Mexico and Guatemala did not differ from the control. More than 80% of the female worms in each country were uninseminated and producing unfertilized oocytes. Nodules containing males differed in each country from the historical control ( < 0.0001), with presence of males ranging from 19.7% in Mexico to 13.6% in Ecuador versus 73% in the control. Nodules with females producing active microfilariae ranged from 7.8% (Mexico) to 2.7% (Ecuador) versus 60% in the historical control ( < 0.0001). Nodules from Ecuador and Mexico were significantly smaller in size than those from Guatemala or historical controls ( < 0.0005). These results depict a deteriorating condition of adult populations in Mexico, Guatemala and Ecuador, indicating that semi-annual ivermectin treatment of ≥6 years has had a profound effect on survival and reproduction of this species.

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2004-11-01
2017-11-22
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  • Received : 24 Mar 2004
  • Accepted : 29 Apr 2004

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