1921
Volume 71, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Data from a six-year follow-up of -infected adolescents enrolled in a randomized, double-blind, clinical trial of benznidazole showed successful chemotherapy in 64.7% (95% confidence interval [CI] = 50.2–78.7) and 84.7% (95% CI = 66.8–92.9), respectively, by intention-to treat and by per protocol analysis measured by seronegativity in a chemiluminescent enzyme-linked immunosorbent assay with a purified trypomastigote mucin antigen. No incident case of cardiomyopathy was detected by electrocardiogram assessment in this cohort of adolescents who had been infected in childhood. The persistent and consistently long-term negative serologic reactions suggest the absence of the parasite in the treated patients and reinforces the recommendation of early benznidazole chemotherapy for -infected infants as a public health policy in endemic areas.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2004.71.594
2004-11-01
2017-09-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/71/5/0700594.html?itemId=/content/journals/10.4269/ajtmh.2004.71.594&mimeType=html&fmt=ahah

References

  1. World Health Organization. Chagas Disease. Strategic Direction for Research. Available at http://www.who.int/tdr/diseases/chagas/. Accessed March 10, 2004.
  2. de Andrade AL, Zicker F, de Oliveira RM, Almeida Silva S, Luquetti A, Travassos LR, Almeida IC, de Andrade SS, de Andrade JG, Martelli CMT, 1996. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 348 : 1407–1413.
  3. Sosa Estani S, Segura EL, Ruiz AM, Velazquez E, Porcel BM, Yampotis C, 1998. Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas’ disease. Am J Trop Med Hyg 59 : 526–529.
  4. Almeida IC, Covas DT, Soussumi LM, Travassos LR, 1997. A highly sensitive and specific chemiluminescent enzyme-linked immunosorbent assay for diagnosis of active Trypanosoma cruzi infection. Transfusion 37 : 850–857.
  5. Smith PG, 1987. Evaluating interventions against tropical diseases. Int J Epidemiol 16 : 159–166.
  6. Galvão LMC, Chiari E, Macedo AM, Luquetti AO, Silva SA, Andrade AL, 2003. PCR as a tool for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy. J Clin Microbiol 41 : 5066–5070.
  7. de Andrade AL, Zicker F, Rassi A, Rassi AG, Oliveira RM, Silva SA, de Andrade SS, Martelli CMT, 1998. Early electrocardiographic abnormalities in Trypanosoma cruzi-seropositive children. Am J Trop Med Hyg 59 : 530–534.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2004.71.594
Loading
/content/journals/10.4269/ajtmh.2004.71.594
Loading

Data & Media loading...

  • Received : 27 Mar 2004
  • Accepted : 13 May 2004

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error