Volume 71, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Data from a six-year follow-up of -infected adolescents enrolled in a randomized, double-blind, clinical trial of benznidazole showed successful chemotherapy in 64.7% (95% confidence interval [CI] = 50.2–78.7) and 84.7% (95% CI = 66.8–92.9), respectively, by intention-to treat and by per protocol analysis measured by seronegativity in a chemiluminescent enzyme-linked immunosorbent assay with a purified trypomastigote mucin antigen. No incident case of cardiomyopathy was detected by electrocardiogram assessment in this cohort of adolescents who had been infected in childhood. The persistent and consistently long-term negative serologic reactions suggest the absence of the parasite in the treated patients and reinforces the recommendation of early benznidazole chemotherapy for -infected infants as a public health policy in endemic areas.


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  • Received : 27 Mar 2004
  • Accepted : 13 May 2004
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