1921
Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We report a case of a 56-year-old man with a history of splenectomy for idiopathic thrombocytopenic purpura who developed persistent bacteremia in the acute phase of human bartonellosis. This patient did not develop hemolytic anemia. Only after several courses of antibiotic treatment was the infection eradicated. This is an unusual case of overwhelming post-splenectomy infection by , which provides clinical evidence that the spleen is a critical effector organ of clearance of this infection as well as the effector organ of bartonellosis-associated hemolytic anemia.

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2004-07-01
2017-11-18
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References

  1. Maguina C, Garcia P, Gotuzzo E, Spach D, 2001. Bartonellosis (Carrion’s disease) in the modern era. Clin Infect Dis 33 : 772–779.
  2. Chamberlin J, Laughlin L, Romero S, Solorzano N, Gordon S, Andre R, Pachas P, Friedman H, Ponce C, Watts D, 2002. Epidemiology of endemic Bartonella bacilliformis: a prospective cohort study in a Peruvian mountain valley community. J Infect Dis 186 : 983–990.
  3. Karem K, 2000. Immune aspects of Bartonella. Crit Rev Microb 26 : 133–145.
  4. Henriquez C, Infante B, Merello J, Gallino M, Santivañez L, Maguiña C, Guerra H, Birtles R, Ventosilla P, 2002. Identificación de Bartonella bacilliformis por métodos moleculares. Rev Med Hered 13 : 58–63.
  5. Mallqui V, Speelmon E, Verastegui M, Gillman R, 2000. Sonicated diagnostic immunoblot for bartonellosis. Clin Diagn Lab Immunol 7 : 1–5.
  6. Benson L, Kar S, McLaughlin G, Ihler G, 1986. Entry of Bartonella bacilliformis into erythrocytes. Infect Immun 54 : 347–353.
  7. Sobraques M, Maurin M, Birtles R, Raoult D, 1999. In vitro susceptibilities of four Bartonella bacilliformis strains to 30 antibiotic compounds. Antimicrob Agents Chemother 43 : 2090–2092.
  8. Reynafarje C, Ramos J, 1961. The hemolytic anemia of human bartonellosis. Blood 17 : 562–578.
  9. Jandl JH, 1996. The spleen and hypersplenism. Strangis JT, ed. Blood: Textbook of Hematology. Second edition. Philadelphia: Lippincott Williams & Wilkins, 577–603.
  10. Chotivanich K, Udomsangpetch R, McGready R, Proux S, Newton P, Pukrittayakamee S, Looareesuwan S, White N, 2002. Central role of the spleen in malaria parasite clearance. J Infect Dis 185 : 1538–1541.
  11. Looareesuwan S, Suntharasamai P, Webster H, Ho M, 1993. Malaria in splenectomized patients. Report of four cases and review. Clin Infect Dis 16 : 361–366.
  12. Davidson R, Wall R, 2001. Prevention and management of infections in patients without a spleen. Clin Microbiol Infect 7 : 657–660.
  13. Weinman D, Pinkerton H, 1937. Carrion’s disease III. Experimental production in animals. Proc Soc Exp Biol Med 37 : 594–595.
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  • Received : 17 Sep 2003
  • Accepted : 17 Oct 2003

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