Volume 71, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The Th1 response elicited in mice infected with has been used as a model to characterize cellular immune defects associated with infection. However, it is not known if the immune response associated with the infection by virulent parasites can promote resistance to a subsequent infection. Our data demonstrate that C3HeB/FeJ mice infected subcutaneously with virulent are resistant to an challenge. The healing phenotype is characterized by a Th1 response as measured by increased production of interferon-γ and low levels of interleukin-4 in the draining lymph node. Together, this indicates that the Th1 response associated with infection can promote resistance to infection and that it can be used as a tool to study the immune defects associated with infection.


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  • Received : 12 Dec 2003
  • Accepted : 03 Jun 2004

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