Volume 71, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Leishmaniasis has increased in importance in recent years because infection with human immunodeficiency virus (HIV) has emerged as a risk factor for this disease. However, the actual prevalence of leishmaniasis in the general population of Spain is unknown. We present a study of the seroprevalence of infection with in the general population of Castilla-Leon, Spain. A random sample of individuals presenting to health care clinics (4,825 sera) and of HIV-infected patients in the autonomous community of Castilla-Leon was collected in 1996. The sero-prevalence of antibodies to was determined by an indirect enzyme immunoassay and found to be 4.9% in the general population. There was a significant increase in seroprevalence with age ( = 0.001), from 3.96% in those 14–20 years old to 7.2% in those > 70 years old. There were no significant differences between women and men (5.0% versus 4.9%; = 0.9534). Seroprevalence was significantly higher in people from rural areas than in those from cities (6.0% versus 3.4%; = 0.001). Patients infected with HIV had a seroprevalence for of 64.0%. No differences were observed between women and men, and prevalence did not increase with age.


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  1. Anonymous, 2000. Leishmaniasis and leishmania/HIV co-infection. WHO Report on Global Surveillance of Epidemic-Prone Infectious Diseases. Geneva: World Health Organization, WHO/CDS/CSR/ISR/2000.1, 121–127.
  2. Alvar J, Cañavate C, Gutiérrez-Solar B, Jiménez M, Laguna F, Lopez-Vélez R, Molina R, Moreno J, 1997. Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev 10 : 298–319. [Google Scholar]
  3. Alvar J, Gutiérrez-Solar B, Pachon I, Calbacho E, Ramírez M, Vallés R, Guillén JL, Cañavate C, Amela C, 1996. AIDS and Leishmania infantum. New approaches for a new epidemiogical problem. Clin Dermatol 14 : 541–546. [Google Scholar]
  4. Acedo C, Martín J, Vélez ID, Sanchís MC, Louassini M, Maldonado JA, Morillas F, 1996. Leishmaniasis eco-epidemiology in the Alpujarra region (Granada province, southern Spain). Int J Parasitol 25 : 303–310. [Google Scholar]
  5. Morillas F, Sánchez F, Ocaña J, Martín-Sánchez J, Ocaña-Wihelmi J, Acedo C, Sanchiz-Marín MC, 1996. Leishmaniosis in the focus of the Axarquía region, Málaga province, southern Spain: a survey of the human, dog, and vector. Parasitol Res 82 : 569–570. [Google Scholar]
  6. Botet J, Portús M, 1993. La leishmaniosis en la España Peninsular. Revision historicobibliográfica (1912–1985). Rev San Hig Publica 67 : 255–266. [Google Scholar]
  7. Centro Nacional de Epidemiología, 1996. Instituto de Salud Carlos III (España). Bol Epidemiol Semin 4 : 393–404. [Google Scholar]
  8. Moral L, Rubio EM, Moya M, 2002. A leishmanin skin test survey in the human population of l’Alacanti region (Spain): implications for the epidemiology of Leishmania infantum infection in southern Europe. Trans R Soc Trop Med Hyg 96 : 129–132. [Google Scholar]
  9. Medrano FJ, Cañavate C, Leal M, Rey C, Lissen E, Alvar J, 1998. The role of serology in the diagnosis and prognosis of visceral leishmaniasis in patients coinfected with human immunodeficiency virus type-1. Am J Trop Med Hyg 59 : 155–162. [Google Scholar]
  10. Pintado V, Martín-Rabadán P, Rivera ML, Moreno S, Bouza E, 2001. Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study. Medicine (Baltimore) 80 : 54–73. [Google Scholar]
  11. Scott P, Pearce E, Natovitz P, Sher A, 1987. Vaccination against cutaneous leishmaniasis in a murine model. J Immunol 139 : 221–227. [Google Scholar]
  12. Marty P, Lelievre A, Quaranta JF, Rahal A, Gari-Toussaint M, Le Fichoux Y, 1994. Use of the leishmanin skin test and Western blot analysis for epidemiological studies in visceral leishmaniasis areas: experience in highly endemic focus in Alpes-Maritimes (France). Trans R Soc Trop Med Hyg 88 : 658–659. [Google Scholar]
  13. Bettini S, Gramiccia M, Gradoni L, Pozio E, Mugnai S, Maroli M, 1983. Leishmaniasis in Tuscany (Italy): VIII. Human population response to leishmanin in the focus of Monte Argentario (Grosseto) and epidemiological evaluation. Ann Parasitol Hum Comp 58 : 539–547. [Google Scholar]
  14. Gutiérrez J, Maroto MC, Piédrola G, Higuera A, 1993. Prevalencia de anticuerpos anti-Leishmania en individuos adictos a drogas por vía parenteral. Rentabilidad de dos técnicas de estudio. Med Clin (Barc) 100 : 168–170. [Google Scholar]
  15. Kar K, 1995. Serodiagnosis of leishmaniasis. Crit Rev Microbiol 21 : 123–152. [Google Scholar]
  16. Wernek GL, Rodrigues L, Santos MV, Araujo IB, Moura LS, Lima SS, Gomes RBB, Maguire JH, Costa CHN, 2002. The burden of Leishmania chagasi infection during an urban outbreak of visceral leishmaniasis in Brazil. Acta Trop 83 : 13–18. [Google Scholar]
  17. Evans TG, Teixeira MJ, McAuliffe IT, Vasconcelos I, Vasconcelos AW, de Queiroz Sousa A, Oliveira Lima JW, Pearson RD, 1992. Epidemiology of visceral leishmaniasis in northeast Brazil. J Infect Dis 166 : 1124–1132. [Google Scholar]
  18. El-Safi SH, Bucheton B, Kheir MM, Musa HA, El-Obaid M, Hammad A, Dessein A, 2002. Epidemiology of visceral leishmaniasis in Atbara River area, eastern Sudan: the outbreak of Barbar El Fugara village (1996–1997). Microbes Infect 4 : 1439–1447. [Google Scholar]

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  • Received : 08 Jul 2003
  • Accepted : 01 Oct 2003

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