1921
Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The polymorphisms in the multidrug resistance 1 () and chloroquine resistance transporter () genes which are associated with chloroquine resistance, were examined in 48 isolates from uncomplicated malaria patients from the West Lombok District in Indonesia. The point mutation N86Y in was present in 35.4% of the isolates and mutation K76T in was found in all but one of the samples studied. Identified haplotypes were mainly identical to the Papua New Guinea type SVMNT (42 of 48, 87.5%), and a few isolates had the Southeast Asia type CVIET (5 of 48, 10.4%). Moreover, one isolate harbored the K76N mutation, giving rise to the haplotype CVMNN, which was not previously reported in field isolates. Our findings suggest that chloroquine resistance in this area might have the same origin as in Papua New Guinea.

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2004-07-01
2017-11-19
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  • Received : 16 Dec 2003
  • Accepted : 04 Feb 2004

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