Volume 71, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Helminth infections elicit an immune response potentially enhancing susceptibility to mycobacterial diseases. Schistosomiasis and infection with show a remarkable similarity in epidemiologic characteristics in Ghana. In 2000, a case-control study was conducted in three districts in Ghana endemic for . One hundred six patients with confirmed disease and 106 matched community controls were included. Schistosome infection of these patients and controls was measured by an enzyme-linked immunosorbent assay that detected circulating anodic antigen in serum. Fifty percent of the participants tested positive for schistosomiasis. There was no difference in detection rates among patients and matched controls. Similarly, there were no differences in worm burden between patients and controls. These results do not support the hypothesis that susceptibility to disease is driven by a co-infection with schistosomes.


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  • Received : 22 Aug 2003
  • Accepted : 22 Apr 2004

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