Volume 71, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


This study evaluates cross-immunity in rhesus monkeys () previously infected with one species of and have had self-cured disease or were cured by antimony-based therapy upon development of full-blown disease. We found that a self-healing cutaneous leishmaniasis (CL) following experimental infection with induces significant protection for and , and was dependent on time of re-challenge by after animals had recovered from primary lesions, but lacked protection against . In contrast, monkeys that recovered from CL or visceral leishmaniasis following chemotherapeutic intervention were protected by challenge with and . These findings indicate the relative variability in protection after self-cure or drug-cured experimental leishmaniasis to challenge by heterologous leishmanial parasites. Further studying the immune response may provide information regarding relevant factors influencing cross-protective immunity.


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  • Received : 09 Apr 2003
  • Accepted : 27 Aug 2003

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