1921
Volume 71, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Amodiaquine (AQ) is currently a major candidate for new antimalarial combinations, although and tests have been rarely simultaneously investigated. The efficacy of AQ was assessed at the dose of 30 mg/kg in treating malaria attacks in 74 children from southeast Gabon, and the activity of monodesethylamodiaquine (MdAQ), the main metabolite of AQ, was measured against parasites isolated from these children. Treatment failures were observed in 40.5% of the children, while 5.4% of the isolates showed resistance to MdAQ. No relationship was observed between and susceptibility. The activities of MdAQ and chloroquine were correlated. The reasons for such disparities between and AQ activities are discussed and the issue of the validity of tests to measure AQ efficacy is raised.

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2004-09-01
2017-11-17
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  • Received : 23 Jan 2004
  • Accepted : 09 Apr 2004

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