1921
Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

CD8 and CD4 T cells are involved in immunity to the pre-erythrocytic stage of malaria. This study has been undertaken to define T cell epitopes on the circumsporozoite protein (CSP) and to analyze the early induction of immune response following infection. We identified CD4 and CD8 T epitopes recognized by different strains of mice as well as by humans. The CD4 T cell response in mice was found to be similar in all strains, but variation between strains was evident. Five H-2-restricted CD8 cytotoxic T lymphocyte (CTL) epitopes, but no H-2-or H-2-restricted epitopes, could be defined. Non-H-2 genes were also able to regulate the response. In recently infected Thai adults, poor immunoresponsiveness was demonstrated. CTL activity and proliferative responses of T cells from malaria-exposed donors were very low. In contrast, exposed individuals had specific antibodies against the immunodominant repeats of both common strains of the CSP; however, titers decreased following treatment.

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2004-07-01
2017-09-26
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  • Received : 02 Apr 2003
  • Accepted : 29 Oct 2003

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