1921
Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

It is difficult to completely eradicate strongyloidiasis, a human intestinal nematode infection with with drugs, especially in males. To find host factors involved in the response to treatment, patients infected with were examined for -specific antibody titers and the effect of treatment with albendazole on these titers were determined. The cure rate was slightly but not significantly lower in males than in females ( = 0.108). However, a significantly higher titer of -specific IgG4 antibody was observed in males than in females ( = 0.0097), and the -specific IgG4 antibody titer was significantly higher in the male non-cured group than in the cured group ( = 0.035). These results suggest that elevation of the -specific IgG4 antibody titer is associated with resistance to treatment of infection, especially in males.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2004.71.107
2004-07-01
2019-03-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/71/1/0700107.html?itemId=/content/journals/10.4269/ajtmh.2004.71.107&mimeType=html&fmt=ahah

References

  1. Sato Y, Toma H, Takara M, Shiroma Y, 1990. Application of enzyme-linked immunosorbent assay for mass examination of strongyloidiasis in Okinawa, Japan. Int J Parasitol 20 : 1025–1029. [Google Scholar]
  2. Satoh M, Tsukidate S, Fujita K, Yamamoto K, 1991. Strongy-loidiasis influences the elevation of adult T-cell leukemia-associated antigen antibody titer. Int Arch Allergy Appl Immunol 96 : 95–96. [Google Scholar]
  3. Grove DI, 1996. Human strongyloidiasis. Adv Parasitol 38 : 251–309. [Google Scholar]
  4. Heyworth MF, 1996. Parasitic diseases in immunocompromised hosts. Cryptosporidiosis, isosporiasis and strongyloidiasis. Gastroenterol Clin North Am 25 : 691–707. [Google Scholar]
  5. Lessnau KD, Can S, Talavera W, 1993. Disseminated Strongyloides stercoralis in human immunodeficiency virus-infected patients. Treatment failure and a review of the literature. Chest 104 : 119–122. [Google Scholar]
  6. Shikiya K, Zaha O, Niimura S, Nakamura H, Nakayoshi T, Kochi A, Uehara T, Uechi H, Ohshiro J, Kinjo F, Saito A, 1992. Clinical study of eradicated and resistant patients to treatment with ivermectin for strongyloidiasis. Kansenshogaku Zasshi 66 : 935–943. [Google Scholar]
  7. Kobayashi J, Sato Y, Toma H, Tasaki T, Takara M, Shiroma Y, 1996. Sex-related defferent efficacy of chemotherapy on human strongyloidiasis in Okinawa. Jpn J Parasitol 45 : 350–354. [Google Scholar]
  8. Fallon PG, Cooper RO, Probert AJ, Doenhoff MJ, 1992. Immune-dependent chemotherapy of schistosomiasis. Parasitology 105 : S41–S48. [Google Scholar]
  9. Webster M, Libranda-Ramirez BDL, Aligui GD, Olveda RM, Ouma JH, Kariuki HC, Kimani G, Olds GR, Fulford AJC, Butterworth AE, Dunne DW, 1997. The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines. Parasitology 114 : 383–393. [Google Scholar]
  10. Arakaki T, Hasegawa H, Asato R, Ikeshiro T, Kinjo F, Saito A, Iwanaga M, 1988. A new method to detect Strongyloides stercoralis from human stool. Jpn J Trop Med Hyg 16 : 11–17. [Google Scholar]
  11. Yoshida M, Seiki M, Yamaguchi K, Takatsuki K, 1984. Mono-clonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci USA 81 : 2534–2537. [Google Scholar]
  12. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I, 1981. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 78 : 6476–6480. [Google Scholar]
  13. Atkins NS, Lindo JF, Lee MG, Conway DJ, Bailey JW, Robinson RD, Bundy DAP, 1997. Humoral responses in human strongyloidiasis: correlations with infection chronicity. Trans R Soc Trop Med Hyg 91 : 609–613. [Google Scholar]
  14. Sato Y, Takara M, Otsuru M, 1985. Detection of antibodies in strongyloidiasis by enzyme-linked immunosorbent assay (ELISA). Trans R Soc Trop Med Hyg 79 : 51–55. [Google Scholar]
  15. Sakaguchi M, Inouye S, 1987. Fluorometric enzyme-linked immunosorbent assay for the measurement of IgE antibody to mite Dermatophagoides farinae. Microbiol Immunol 31 : 711–715. [Google Scholar]
  16. Abraham D, Rotman HL, Haberstroh HF, Yutanawiboonchai W, Brigandi RA, Leon O, Nolan TJ, Schad GA, 1995. Strongyloides stercoralis: protective immunity to third- stage larvae in BALB/cByj mice. Exp Parasitol 80 : 297–307. [Google Scholar]
  17. Brigandi RA, Rotman HL, Yutanawiboonchai W, Leon O, Nolan TJ, Schad GA, Abraham D, 1996. Strongyloides stercoralis: role of antibody and complement in immunity to the third stage of larvae in BALB/cByj mice. Exp Parasitol 82 : 279–289. [Google Scholar]
  18. Atkins NS, Conway DJ, Lindo JF, Bailey JW, Bundy DA, 1999. L3 antigen-specific antibody isotype responses in human strongyloidiasis: correlations with larval output. Parasite Immunol 21 : 517–526. [Google Scholar]
  19. Dam GJ, Stelma FF, Gryseels B, Ferreira STM, Talla I, Niang M, Rotmans JP, Deelder AM, 1996. Antibody response patterns against Schistosoma mansoni in a recently exposed community in Senegal. J Infect Dis 173 : 1232–1241. [Google Scholar]
  20. Hagan P, Blumenthal UJ, Dunn D, Simpson AJG, Wilkins HA, 1991. Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 349 : 243–245. [Google Scholar]
  21. Kwan-lim GE, Forsyth KP, Maizels RM, 1990. Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection. J Immunol 145 : 4298–4305. [Google Scholar]
  22. Rihet P, Demeure CE, Dessein AJ, Bourgois A, 1992. Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area. Eur J Immunol 22 : 2063–2070. [Google Scholar]
  23. Robinson RD, Lindo JF, Neva FA, Gam AA, Vogel P, Terry SI, Cooper ES, 1994. Immunoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica. J Infect Dis 169 : 692–696. [Google Scholar]
  24. Barrett KE, Neva FA, Gam AA, Cicmanec J, London WT, Phillips JM, Metcalfe DD, 1988. The immune response to nematode parasites: modulation of mast cell numbers and function during Strongyloides stercoralis infections in nonhuman primates. Am J Trop Med Hyg 38 : 574–581. [Google Scholar]
  25. Haarbrink M, Terhell AJ, Abadi K, Asri M, de Medeiros F, Yazdanbakhsh M, 1999. Anti-filarial IgG4 in men and women living in Brugia malayi-endemic areas. Trop Med Int Health 4 : 93–97. [Google Scholar]
  26. Naus CW, Booth M, Jones FM, Kemijumbi J, Vennervald BJ, Kariuki CH, Ouma JH, Kabatereine NB, Dunne DW, 2003. The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community. Trop Med Int Health 8 : 561–568. [Google Scholar]
  27. Ohashi Y, Nakai Y, Tanaka A, Kakinoki Y, Washio Y, Kato A, Masamoto T, Yamada K, Hayashi M, 1998. Serologic study of the working mechanisms of immunotherapy for children with perennial allergic rhinitis. Arch Otolaryngol Head Neck Surg 124 : 1337–1346. [Google Scholar]
  28. Moverare R, Vesterinen E, Metso T, Sorva R, Elfman L, Haahtela T, 2001. Pollen-specific rush immunotherapy: clinical efficacy and effects on antibody concentrations. Ann Allergy Asthma Immunol 86 : 337–342. [Google Scholar]
  29. Park HS, Nahm DH, Kim HY, Suh YJ, Cho JW, Kim SS, Lee SK, Jung KS, 2001. Clinical and immunologic changes after allergen immunotherapy with Hop Japanese pollen. Ann Allergy Asthma Immunol 86 : 444–448. [Google Scholar]
  30. Leynadier F, Banoun L, Dollois B, Terrier P, Epstein M, Guinnepain MT, Firon D, Traube C, Fadel R, Andre C, 2001. Immunotherapy with a calcium phosphate- adsorbed five grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study. Clin Exp Allergy 31 : 988–996. [Google Scholar]
  31. Yazdanbakhsh M, Kremsner PG, Ree R, 2002. Allergy, parasites, and the hygiene hypothesis. Science 296 : 490–494. [Google Scholar]
  32. Wachholz PA, Durham SR, 2003. Induction of ‘blocking’ IgG antibodies during immunotherapy. Clin Exp Allergy 33 : 1171–1174. [Google Scholar]
  33. Ash L, 1971. Preferential susceptibility of male jirds (Meriones uniculatus) to infection with Brugia pahangi. J Parasitol 57 : 777–780. [Google Scholar]
  34. Benten WPM, Wunderlich F, Hermann R, Kuhn-Velten WN, 1993. Testosterone-induced compared with oestradiol-induced immunosuppression against Plasmodium chabaudai malaria. J Endocrinol 139 : 487–494. [Google Scholar]
  35. Kiyota M, 1984. Regulatory role of testosterone on the natural defence mechanism against infection with Strongyloides ratti in C57BL/6 mice. Jpn J Parasitol 33 : 49–54. [Google Scholar]
  36. Kiyota M, Korenaga M, Nawa Y, Kotani M, 1984. Effect of androgen on the expression of the sex-difference in susceptibility to infection with Strongyloides ratti in C57BL/6 mice. Aust J Exp Biol Med Sci 62 : 607–618. [Google Scholar]
  37. Rivero JC, Inoue Y, Murakami N, Horii Y, 2002. Androgen- and estrogen-dependent sex differences in host resistance to Strongyloides venezuelensis infection in Wistar rats. J Vet Med Sci 64 : 457–461. [Google Scholar]
  38. Abe T, Kiyota M, Nawa Y, 1985. Strongyloides ratti: increase in susceptibility to infection following blockade of the mono-nuclear phagocyte system in female mice. Aust J Exp Biol Med Sci 63 : 651–653. [Google Scholar]
  39. Watanabe K, Hamano S, Noda K, Koga M, Tada I, 1999. Strongyloides ratti: additive effect of testosterone implantation and carbon injection on the susceptibility of female mice. Parasitol Res 85 : 522–526. [Google Scholar]
  40. Kanda N, Tsuchida T, Tamaki K, 1996. Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells. Clin Exp Immunol 106 : 410–415. [Google Scholar]
  41. Alexander J, Stimson WH, 1988. Sex hormones and the course of parasitic infection. Parasitol Today 4 : 189–193. [Google Scholar]
  42. Capece BPS, Castells G, Perez F, Arboix M, Cristofol C, 2000. Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep. Vet Res Commun 24 : 339–348. [Google Scholar]
  43. Mirfazaelian A, Dadashzadeh S, Rouini MR, 2002. Effect of gender in the disposition of albendazole metabolites in humans. Eur J Clin Pharmacol 58 : 403–408. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2004.71.107
Loading
/content/journals/10.4269/ajtmh.2004.71.107
Loading

Data & Media loading...

  • Received : 14 Nov 2003
  • Accepted : 10 Mar 2004

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error