Volume 71, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


It is difficult to completely eradicate strongyloidiasis, a human intestinal nematode infection with with drugs, especially in males. To find host factors involved in the response to treatment, patients infected with were examined for -specific antibody titers and the effect of treatment with albendazole on these titers were determined. The cure rate was slightly but not significantly lower in males than in females ( = 0.108). However, a significantly higher titer of -specific IgG4 antibody was observed in males than in females ( = 0.0097), and the -specific IgG4 antibody titer was significantly higher in the male non-cured group than in the cured group ( = 0.035). These results suggest that elevation of the -specific IgG4 antibody titer is associated with resistance to treatment of infection, especially in males.


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  • Received : 14 Nov 2003
  • Accepted : 10 Mar 2004

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